Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Reduced responsiveness to epoetin at re-exposure after prolonged epoetin-free period in anemic hemodialysis patients with end-stage renal disease

Milutinović, Slobodan and Trkulja, Vladimir (2006) Reduced responsiveness to epoetin at re-exposure after prolonged epoetin-free period in anemic hemodialysis patients with end-stage renal disease. Croatian Medical Journal, 47 (3). pp. 424-432. ISSN 0353-9504 (Print) 1332-8166 (Electronic)

[img]
Preview
PDF
Download (693Kb) | Preview
    Official URL: http://www.cmj.hr/

    English abstract

    AIM: To determine if temporary discontinuation of epoetin therapy in anemic patients with end stage renal disease (ESRD) influences their responsiveness to epoetin. - - - - - METHODS: We performed a post hoc analysis of the data from two consecutive single-center randomized trials (T1 and T2) comparing the efficacy of two epoetin products (E1 and E2) in anemic patients with ESRD. The analysis included a subset of 44 patients who participated in both trials and were not receiving epoetin in the period (median, 12 months; range 5-15) between the trials due to epoetin shortage. Two co-primary outcomes were average weekly hemoglobin difference from the baseline and average weekly epoetin dose. - - - - - RESULTS: With adjustment for potential differences between E1 and E2, average weekly hemoglobin difference of 1.21 g/dL from the baseline was lower in T2 than that of 1.71 g/dL in T1: difference -0.49 (95% confidence interval [CI], -0.68 to -0.29; P<0.001). Average weekly epoetin dose of 107 IU/kg in T2 was higher than 96 IU/kg in T1 (ratio, 1.13; 95% CI, 1.04-1.24; P=0.009). With additional adjustment for within-subject changes in baseline covariates from T1 to T2 (baseline hemoglobin, body mass index, serum albumin, ferritin and transferrin saturation, intact parathormone, C-reactive protein, dialysis dose, and use of angiotensin converting enzyme inhibitors), hemoglobin response remained lower (adjusted difference, -0.44 g/dL; 95% CI, -0.73 to -0.16; P=0.004) and weekly epoetin dose remained higher in T2 than inT1 (adjusted ratio, 1.17; 95% CI, 1.03-1.34; P=0.016). - - - - - CONCLUSIONS: In patients with ESRD, responsiveness to epoetin was lower in T2 after a period of epoetin therapy discontinuation than in T1 epoetin trial. Since this could not be explained by within-subject changes in factors known to affect response to epoetin, a prolonged withdrawal of epoetin in patients with ESRD might independently contribute to a reduced responsiveness to epoetin at a later re-exposure. - - - - - CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov Identifier for T1 trial: NCT00322413.

    Item Type: Article
    MeSH: Anemia - blood - drug therapy - etiology ; Epoetin Alfa - therapeutic use ; Erythropoietin, Recombinant - therapeutic use ; Kidney Failure, Chronic - complications ; Renal Dialysis ; Comparative Study ; Hemoglobins - analysis ; Humans ; Middle Aged ; Randomized Controlled Trials ; Treatment Outcome
    Divisions: Katedra za farmakologiju
    Depositing User: Lea Škorić
    Status: Published
    Creators:
    CreatorsEmail
    Milutinović, Slobodan
    Trkulja, Vladimir
    Date: June 2006
    Date Deposited: 11 Dec 2006
    Last Modified: 23 Sep 2011 18:09
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/60

      Actions (login required)

      View Item

      Document Downloads

      More statistics for this item...