Stipčević, Tamara and Kusačić-Kuna, Sanja and Deželjin, Martina and Dodig, Damir and Koršić, Mirko and Pivac, Nela and Mück-Šeler, Dorotea
Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients.
Hormone research, 71 (4).
ISSN 0301-0163 (Print) 1423-0046 (Electronic)
BACKGROUND/AIM: The relationship between the hypothalamic-pituitary-thyroid (HPT) axis and the serotonergic (5-hydroxytryptamine, 5-HT) system is not clear. The aim of the study was to determine platelet biochemical markers (5-HT concentration and monoamine oxidase B, MAO-B, activity) in hypothyroid patients. ----- METHODS: The study included 25 medication-free female hypothyroid patients in postoperative follow-up after total thyroidectomy due to papillary thyroid carcinoma, who had not been treated with synthetic thyroxine (T(4)) for 4 weeks, and 44 age-matched euthyroid healthy women. The platelet 5-HT concentration, platelet MAO-B activity, total T(4) and thyroid-stimulating hormone (TSH) levels were determined using spectrofluorimetric methods, radioimmunoassay and fluoroimmunoassay, respectively. ----- RESULTS: Hypothyroid patients had significantly higher TSH, significantly lower T(4) levels and platelet 5-HT concentrations, and unchanged platelet MAO-B activity than healthy subjects. A positive correlation was found between the 5-HT concentration and platelet MAO-B activity, and between the platelet MAO-B activity and T(4) in control subjects. ----- CONCLUSIONS: Reduced platelet 5-HT concentrations in hypothyroid patients suggests a complex interaction between the 5-HT system and HPT axis activity, which could be related to the frequent occurrence of depressive symptoms in hypothyroid patients. The determination of platelet 5-HT concentrations should be considered a diagnostic tool for the evaluation of depressive symptoms in hypothyroid patients during the hormone withdrawal procedure.
||Adult ; Aged ; Blood Platelets/metabolism ; Female ; Humans ; Hypothyroidism/blood ; Hypothyroidism/enzymology ; Middle Aged ; Monoamine Oxidase/blood ; Serotonin/blood ; Substance Withdrawal Syndrome/blood ; Thyrotropin/blood ; Thyroxine/blood
||Katedra za internu medicinu
||4 March 2009
||29 Sep 2009
||23 Sep 2011 16:10
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