Comparison of occurrence of upper urinary tract carcinomas in the region with endemic villages and non-endemic nephropathy region in Croatia

Belicza, Mladen and Demirović, Alma and Tomić, Karla and Leniček, Tanja and Pavić, Ivana and Jakovina, Krunoslav and Vukelić, Mato and Jakovina, Tratinčica and Mišić, Maja and Krušlin, Božo (2008) Comparison of occurrence of upper urinary tract carcinomas in the region with endemic villages and non-endemic nephropathy region in Croatia. Collegium Antropologicum, 32 (4). pp. 1203-1207. ISSN 0350-6134

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Abstract

Balkan endemic nephropathy (BEN) is a chronic tubulointerstitial renal disease of a still unknown etiology, associated with an increased frequency of urothelial carcinoma, particularly of the upper urinary tract (UUT). The aim of the study was to compare the occurrence of UUT carcinomas between Brodsko-Posavska Region (BPR) which is the region with endemic villages and the non-endemic region of Zagreb (ZG) in two six-year periods with a 20 year period separating the two, pointing out a possible difference in occurrence regarding war in Croatia (1991-1995). Comparing BPR and ZG regions we found a more then 5 times higher frequency of UUT carcinomas in BPR in the first period and more than 4.5 times higher frequency in the second period. Women in BPR were more frequently affected with UUT carcinomas.

Abstract in Croatian

Balkanska endemska nefropatija je kronična tubulointersticijska bolest bubrega nepoznate etiologije koja je povezana s povećanom učestalosti urotelnog karcinoma, osobito urotelnog karcinoma gornjeg mokraćnog sustava. Cilj ovog istraživanja je usporedba pojavnosti karcinoma gornjeg mokraćnog sustava u bolesnika iz Brodsko-Posavske regije (BPR) u kojoj se nalaze endemska naselja i bolesnika iz Zagreba koji je neenedemska regija (ZG), i to u dva šestogodišnja razdoblja razmaknuta dvadeset godina, naglašavajući i moguće razlike u pojavnosti obzirom na rat u Hrvatskoj (1991–1995). Uspoređujući regije BPR i ZG nađena je više od pet puta veća učestalost karcinoma gornjeg mokraćnog sustava u BPR u prvom razdoblju i više od četiri i pol puta veća učestalost karcinoma gornjeg mokraćnog sustava u BPR u drugom razdoblju. Žene u BPR češće obolijevaju od karcinoma gornjeg mokraćnog sustava nego muškarci.

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