Reversible "brain atrophy" in patients with Cushing's disease

Gnjidić, Živko and Sajko, Tomislav and Kudelić, Nenad and Malenica, Maša and Vizner, Branka and Vrkljan, Milan and Hat, Josip and Rumboldt, Zoran (2008) Reversible "brain atrophy" in patients with Cushing's disease. Collegium antropologicum, 32 (4). pp. 1165-1170. ISSN 0350-6134 (Print)

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Abstract

During the past 25 years, we came across 60 patients with corticotroph pituitary adenomas and Cushing's disease. Neuroradiological examination showed prominent volume loss of the brain parenchyma, unexpected for the patient's age. This "brain atrophy" appeared to regress after surgical removal of pituitary adenoma and normalization of cortisol level. Observed difference between degree of "brain atrophy" in the Cushing's disease group and in the control group was statistically significant (p < 0.001). The degree of "brain atrophy" correlated well with the duration of Cushing's disease. Partial reversibility of "brain atrophy" was noticed during the 2nd, 3rd and 4th year after surgery and normalization of cortisol level. Increased cortisol level is one of the causative factors in pathogenesis of "brain atrophy". Loss of brain volume is at least partially reversible after normalization of cortisol levels.

Abstract in Croatian

Unazad 25 godina liječili smo 60 pacijenata sa kortikotropnim adenomima hipofize i Cushingovom bolesti. Neuroradiološko snimanje pokazalo je značajan gubitak volumena moždanog parenhima, neočetkivan za pacijentovu dob. Izgleda da ta »moždana atrofija« regredira nakon kirurškog odstranjenja adenoma hipofize i normalizacije razine kortizola. Razlika u utvrđenoj razini »atrofije mozga« u Cushingovoj bolesti i u kontrolnoj skupini je statistički značajna (p<0,001). Stupanj »moždane atrofije« korelira dobro sa trajanjem Cushingove bolesti. Djelomično povlačenje »atrofije mozga« primijećeno je dvije, tri i četiri godine nakon kirurškog liječenja i normalizacije razine kortizola. Povišena razina kortizola je jedan od uzročnih faktora u patogenezi »moždane atrofije«. Smanjenje volumena mozga je djelomično reverzibilno nakon normalizacije razine kortizola.

Item Type: Article
MeSH: ACTH-Secreting Pituitary Adenoma - complications - pathology ; Adenoma - complications - pathology ; Brain - pathology ; Pituitary ACTH Hypersecretion - etiology - pathology ; Adolescent ; Adult ; Atrophy ; Child ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Young Adult
Departments: Katedra za internu medicinu
Depositing User: Boris Čičovački
Status: Published
Creators:
CreatorsEmail
Gnjidić, ŽivkoUNSPECIFIED
Sajko, TomislavUNSPECIFIED
Kudelić, NenadUNSPECIFIED
Malenica, MašaUNSPECIFIED
Vizner, BrankaUNSPECIFIED
Vrkljan, MilanUNSPECIFIED
Hat, JosipUNSPECIFIED
Rumboldt, ZoranUNSPECIFIED
Date: December 2008
Date Deposited: 01 Oct 2009
Last Modified: 23 Sep 2011 16:10
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/576

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