Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Neuroendocrine breast carcinoma metastatic to renal cell carcinoma and ipsilateral adrenal gland

Ulamec, Monika and Tomas, Davor and Perić-Balja, Melita and Spajić, Borislav and Hes, Ondrej and Krušlin, Božo (2008) Neuroendocrine breast carcinoma metastatic to renal cell carcinoma and ipsilateral adrenal gland. Pathology - research and practice, 204 (11). pp. 851-855. ISSN 0344-0338 (Print)

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    English abstract

    We report on a 60-year-old woman with neuroendocrine carcinoma of the left breast metastasizing to renal cell carcinoma (RCC) of the left kidney and to adrenal gland. A yellow, well-circumscribed tumor, 11 cm in largest diameter and limited to the kidney, was found. Histopathology revealed RCC with foci of neuroendocrine differentiation. Solid sheets of hyperchromatic epithelioid cells with high mitotic activity were found between typical clear cells of RCC. These cells were CAM5,2 and E-cadherin focally positive, synaptophysin and NSE weakly positive, CK19 moderately positive, and AE1-AE3 and EMA strongly positive. Chromogranin A, CD10, CK 14, CK 20, HER2 (score 1+), vimentin, and HMB45 were negative. The left adrenal gland contained multiple, separate foci of a tumor composed of neuroendocrine components. Because of the biphasic tumor in the kidney, extensive clinical examination and further analyses were recommended. Tumor in the left breast was revealed. Two months later, the patient underwent mastectomy with axillary lymph node dissection. The tumor was histologically and immunohistochemically similar to the neuroendocrine component within RCC. All axillary nodes were positive. To our knowledge, this is the first case of neuroendocrine breast carcinoma with metastasis to renal cell carcinoma and ipsilateral adrenal gland.

    Item Type: Article
    MeSH: Breast Neoplasms - metabolism - pathology ; Carcinoma, Neuroendocrine - metabolism - secondary ; Carcinoma, Renal Cell - metabolism - pathology ; Kidney Neoplasms - metabolism - pathology ; Neoplasms, Multiple Primary - pathology ; Adrenal Gland Neoplasms - metabolism - secondary ; Female ; Humans ; Immunohistochemistry ; Middle Aged
    Divisions: Katedra za patologiju
    Depositing User: Boris Čičovački
    Status: Published
    Creators:
    CreatorsEmail
    Ulamec, Monika
    Tomas, Davor
    Perić-Balja, Melita
    Spajić, Borislav
    Hes, Ondrej
    Krušlin, Božo
    Date: November 2008
    Date Deposited: 19 Jan 2009
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/554

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