Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Hyperreactio luteinalis could be a risk factor for development of HELLP syndrome: case report

Grgić, Ozren and Radaković, Branko and Barišić, Dubravko (2008) Hyperreactio luteinalis could be a risk factor for development of HELLP syndrome: case report. Fertility and Sterility, 90 (5). e13-e16. ISSN 0015-0282 (Print) 1556-5653 (Electronic)

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    English abstract

    OBJECTIVE: To report a unique case of hyperreactio luteinalis in pregnancy associated with ovarian torsion and subsequent development of hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. DESIGN: Case report. ----- SETTING: University medical center. ----- PATIENT(S): A 34-year-old primigravida woman with ovarian torsion in 13 weeks of pregnancy and subsequent intrauterine growth restriction (IUGR) and HELLP syndrome. ----- INTERVENTION(S): Laparoscopic salpingo-oophorectomy due to the ovarian torsion and cesarean section (CS) due to the development of HELLP syndrome. ----- MAIN OUTCOME MEASURE(S): HELLP syndrome. ----- RESULT(S): In the first trimester the patient had symptoms of acute abdomen due to the ovarian torsion. Both ovaries were enlarged and multicystic. Hormonal studies confirmed an abnormally elevated level of hCG (192.000 IU/L), mild hyperthireosis, and hyperandrogenemia. Laparoscopic salpingo-oophorectomy was performed. At 30 weeks of pregnancy, IUGR was confirmed sonographically and clinically, and at 33 weeks severe preeclampsia developed. One week later, HELLP syndrome occurred. Emergency CS was preformed, and she delivered a female newborn weighing 1,640 g. Seven days after delivery, blood pressure and hormonal status returned to normal. ----- CONCLUSION(S): Hyperreactio luteinalis due to the abnormally high level of hCG in the first trimester could be a consequence of inappropriate trophoblast invasion and an early sign of subsequently developing preeclampsia, eclampsia, and HELLP syndrome.

    Item Type: Article
    MeSH: Adult ; Cesarean Section ; Chorionic Gonadotropin, beta Subunit, Human/blood ; Emergency Treatment ; Female ; Fetal Growth Retardation/etiology ; Fetal Growth Retardation/surgery ; Fetal Growth Retardation/ultrasonography ; HELLP Syndrome/etiology ; HELLP Syndrome/surgery ; HELLP Syndrome/ultrasonography ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Laparoscopy ; Live Birth ; Ovarian Cysts/complications ; Ovarian Cysts/metabolism ; Ovarian Cysts/surgery ; Ovarian Cysts/ultrasonography ; Ovarian Diseases/etiology ; Ovarian Diseases/surgery ; Ovarian Diseases/ultrasonography ; Ovariectomy ; Pregnancy ; Risk Factors ; Torsion Abnormality/etiology ; Torsion Abnormality/surgery ; Torsion Abnormality/ultrasonography ; Ultrasonography, Prenatal ; Up-Regulation
    Divisions: Katedra za ginekologiju i opstetriciju
    Depositing User: Boris Čičovački
    Status: Published
    Grgić, Ozren
    Radaković, Branko
    Barišić, Dubravko
    Date: November 2008
    Date Deposited: 05 Oct 2009
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
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