Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Vuksan-Ćusa, Bjanka and Marčinko, Darko and Nađ, Sanea and Jakovljević, Miro (2009) Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts. Progress in Neuro-psychopharmacology & Biological Psychiatry, 33 (1). pp. 109-112. ISSN 0278-5846 (Print)

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    English abstract

    Patient with mental illnesses such as schizophrenia and bipolar disorder have an increased prevalence of metabolic syndrome (MetS) and its components compared to general population. Among psychiatric disorders, bipolar disorder ranks highest in suicidality with a relative risk ratio of completed suicide of about 25 compared to the general population. Regarding the biological hypotheses of suicidality, low blood cholesterol level has been extensively explored, although results are still conflicting. The aim of this study was to investigate whether there were differences in the serum cholesterol levels in hospitalized bipolar disorder men patients with history of suicide attempts (N=20) and without suicide attempts (N=20). Additionally, we investigated if there were differences in the prevalence of MetS according to NCEP ATP-III criteria in these two groups of patients. Results of the study indicated significantly lower serum cholesterol levels (p=0.013) and triglyceride levels (p=0.047), in the bipolar disorder men with suicide attempts in comparison to bipolar disorder men without suicide attempts. The overall prevalence of MetS was 11/40 (27.5%). On this particular sample it was higher in the non-attempters 8/20 (40.0%) than in attempters 3/20 (15.0%) bipolar men group, but without statistical significance. Lower concentrations of serum cholesterol might be useful biological markers of suicidality in men with bipolar disorder.

    Item Type: Article
    MeSH: Adult ; Bipolar Disorder/complications ; Bipolar Disorder/metabolism ; Cholesterol/blood ; Humans ; Male ; Metabolic Syndrome X/complications ; Psychiatric Status Rating Scales ; Suicide, Attempted/psychology ; Suicide, Attempted/statistics & numerical data
    Divisions: Katedra za psihijatriju i psihološku medicinu
    Depositing User: Boris Čičovački
    Status: Published
    Vuksan-Ćusa, Bjanka
    Marčinko, Darko
    Nađ, Sanea
    Jakovljević, Miro
    Date: 01 February 2009
    Date Deposited: 21 Sep 2009
    Last Modified: 30 Sep 2011 13:32
    Subjects: /
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