Vladić, Anton and Klarica, Marijan and Bulat, Marin
Dynamics of distribution of (3)H-inulin between the cerebrospinal fluid compartments.
Brain Research, 1248.
ISSN 0006-8993 (Print) 1872-6240 (Electronic)
Since the distribution of substances between various cerebrospinal fluid (CSF) compartments is poorly understood, we studied (3)H-inulin distribution, over time, after its injection into cisterna magna (CM) or lateral ventricle (LV) or cisterna corporis callosi (CCC) in dogs. After the injection into CM (3)H-inulin was well distributed to cisterna basalis (CB), lumbar (LSS) and cortical (CSS) subarachnoid spaces and less distributed to LV. When injected in LV (3)H-inulin was well distributed to all CSF compartments. However, after injection into CCC (3)H-inulin was mostly localized in CCC and adjacent CSS, while its concentrations were much lower in CM and CB and very low in LSS and LV. Concentrations of (3)H-inulin in venous plasma of superior sagittal sinus and arterial plasma were very low and did not differ significantly, while its concentration in urine was very high. In (3)H-inulin distribution it seems that two simultaneous processes are relevant: a) the pulsation of CSF with to-and-fro displacement of CSF and its mixing, carrying (3)H-inulin in all directions, and b) the passage of (3)H-inulin from CSF into nervous parenchyma and its rapid distribution to a huge surface area of capillaries by vessels pulsations. (3)H-inulin then slowly diffuses across capillary walls into the bloodstream to be eliminated in the urine.
||Absorption ; Animals ; Catheterization ; Cisterna Magna/chemistry ; Diffusion ; Dogs ; Inulin/blood ; Inulin/cerebrospinal fluid ; Inulin/pharmacokinetics ; Inulin/urine ; Lateral Ventricles/chemistry ; Subarachnoid Space/chemistry
||Katedra za farmakologiju
||12 January 2009
||21 Sep 2009
||23 Sep 2011 16:10
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