Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Seroprevalence of herpes simplex virus type 2 in adult HIV-infected patients and blood donors in Croatia

Đaković Rode, Oktavija and Židovec Lepej, Snježana and Begovac, Josip (2008) Seroprevalence of herpes simplex virus type 2 in adult HIV-infected patients and blood donors in Croatia. Collegium antropologicum, 32 (3). pp. 693-695. ISSN 0350-6134 (Print)

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    Croatian abstract

    Prikazani su rezultati istraživanja seroprevalencije virusa herpes simplex tipa 2 (HSV-2) u odraslih osoba u Hrvatskoj te povezanost HSV-2 s dobi, spolom, humanim herpesvirusom tipa 8 (HHV-8) i virusom humane imunodeficijencije (HIV). U presječnu studiju je uključeno 166 HIV-inficiranih pacijenata i 219 dobrovoljnih darovatelja krvi. Protutijela na HSV-2 su određena imunoenzimskim testom koji se temeljio na gG2 rekombinantnim glikoproteinima. Seroprevalencija HSV-2 u HIV-inficiranih pacijenata bila je 45,8%, a u dobrovoljnih darovatelja krvi 8,7% (p<0.0001; OR 8,8; 95% CI 5,05–15,49). Nezavisni prediktori za HSV-2 bili su HIV-infekcija (OR 11,0; 95% CI 5,93–20,41), ženski spol (OR 2,28; 95% CI 1,22–4,26), starija dob (OR 3,93; 95% CI 2,74–7,11) i seropozitivnost HHV-8 (OR 2,72; 95% CI 1,09–6,75). Poznavanje epidemiologije HSV-2 je prvi korak u kreiranju mjera za smanjivanje prijenosa HSV-2 i HIV-a. Povezanost HSV-2 s HIV-infekcijom i protutijelima na HHV-8 upućuje na sličan put prijenosa.

    English abstract

    The present study estimates herpes simplex virus type 2 (HSV-2) seroprevalence and evaluates its association with age, sex, human herpesvirus type 8 (HHV-8) and human immunodeficiency virus (HIV) among adults in Croatia. A cross-sectional survey included 166 HIV-infected patients and 219 blood donors. Antibodies against HSV-2 were determined by enzyme immunoassays based on gG2 recombinant glycoprotein. HSV-2 seroprevalence was 45.8% in HIV-infected patients and 8.7% in blood donors (p < 0.0001; OR 8.8; 95% CI 5.05-15.49). Independent predictors of HSV-2 seropositivity were HIV infection (OR 11.0; 95% CI 5.93-20.41), female gender (OR 2.28; 95% CI 1.22-4.26), older age (OR 3.93; 95% CI 2.74-7.11), and HHV-8 seropositivity (OR 2.72; 95% CI 1.09-6.75). Understanding the epidemiology of HSV-2 is a critical first step in designing interventions to decrease HSV-2 and HIV transmission. The association of HSV-2 with HIV infection and HHV-8 antibodies suggests a similar transmission route.

    Item Type: Article
    MeSH: Blood Donors ; HIV Infections ; Herpes Genitalis - epidemiology - transmission ; Adult ; Aged ; Antibodies, Viral - blood ; Croatia - epidemiology ; Cross-Sectional Studies ; Female ; Herpesviridae Infections - epidemiology - transmission ; Herpesvirus 2, Human - immunology ; Herpesvirus 8, Human - immunology ; Humans ; Male ; Middle Aged ; Seroepidemiologic Studies ; Young Adult
    Divisions: Katedra za infektologiju
    Depositing User: Boris Čičovački
    Status: Published
    Creators:
    CreatorsEmail
    Đaković Rode, Oktavija
    Židovec Lepej, Snježana
    Begovac, Josip
    Date: September 2008
    Date Deposited: 14 Nov 2008
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/523

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