Impaired esophageal function in patients with irritable bowel syndrome

Bilić, Ante and Jurčić, Dragan and Schwarz, Dragan and Marić, Nikolina and Včev, Aleksandar and Marušić, Marinko and Gabrić, Maruška and Špoljarić, Ljubica (2008) Impaired esophageal function in patients with irritable bowel syndrome. Collegium Antropologicum, 32 (3). pp. 747-753. ISSN 0350-6134

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Abstract

The aim of the study was to determine prevalence of the signs and symptoms related to esophageal dysfunction in irritable bowel syndrome (IBS) patients, and to investigate sensorimotor function impairment based on the esophageal manometry study, thus to determine the correlation between them. The study included 30 patients with IBS, 14 of them with diarrhea (IBSd) and 16 with constipation (IBSc) as a predominant discomfort. Control group consisted of 30 healthy subjects. The patients were included in the study on the basis of the Rome criteria for IBS. In addition to thorough history and physical examination patient underwent esophagogastroduodenoscopy and esophageal manometry. The values of esophageal manometry obtained in healthy subjects served as controls in manometry studies. The patients with IBS suffered a great number of both colonic and extracolonic signs and symptoms, however, there was no statistically significant difference in the prevalence of particular symptoms between the two patient subgroups. In comparison with healthy subjects, the patients suffering from IBS showed pathologically altered values in the majority of parameters of esophageal motility. Comparison of the two subgroups of IBS patients according to esophageal motility characteristics yielded differences in only few of them. The results obtained in the study could explain why the patients with IBS quite commonly complain of the symptoms related to upper gastrointestinal tract, such as heartburn and chest pain of noncardiac genesis. The results also suggest that the IBS might be associated with considerably more extensive smooth muscle or innervation changes than presumed before.

Abstract in Croatian

Cilj ove studije je bio odrediti prevalenciju znakova i simptoma povezanih s disfunkcijom jednjaka u bolesnika sa sindromom iritabilnog crijeva (IBS), utvrditi poremećaje senzorimotoričke funkcije jednjaka na temelju manometrijskog ispitivanja te na taj način utvrditi korelaciju među njima. 30 bolesnika sa IBS, 14 s proljevom i 16 s konstipacijom kao predominantnim simptomima je uključeno u studiju. Kontrolna grupa se je sastojala od 30 zdravih ispitanika. Bolesnici su uključeni u studiju na temelju Rimskih kriterija za IBS. Nakon temeljito uzete povijesti bolesti i fizikalnog statusa bolesnicima je učinjena ezofagogastroduodenoskopija i manometrija jednjaka. Vrijednosti manometrije jednjaka dobivene u zdravih ispitanika su služile kao kontrolne vrijednosti za manometrijsko ispitivanje. Bolesnici s IBS su se žalili na veliki broj kako koloničkih tako i ekstrakoloničkih simptoma i znakova, međutim, nije bilo statistički značajne razlike u prevalenciji ovih simptoma između dvije podgrupe IBS bolesnika. U usporedbi sa zdravim ispitanicima bolesnici s IBS imali su patološki promjenjene vrijednosti većine parametara motiliteta jednjaka. Komparacija dviju podgrupa bolesnika s IBS je pokazala razlike samo u pojedinim manometrijskim parametrima. Rezultati dobiveni u ovoj studiji bi mogli objasniti zašto bolesnici s IBS često imaju simptome povezane s gornjim dijelom gastrointestinalnog trakta, kao što su žgaravica i bol u prsima nekardiogenog uzroka. Rezultati također sugeriraju da bi IBS mogao biti povezan sa značajno proširenijim promjenama inervacije glatke muskulature nego što se dosada mislilo.

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