Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings

Sporiš, Davor and Hajnšek, Sanja and Boban, Marina and Bašić, Silvio and Petrović, Ratimir and Radoš, Marko and Babić, Tomislav (2008) Epilepsy due to malformations of cortical development: correlation of clinical, MRI and Tc-99mECD SPECT findings. Collegium antropologicum, 32 (2). pp. 345-350. ISSN 0350-6134 (Print)

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    Croatian abstract

    Malformacije kortikalnog razvoja (MKR) sve se više raspoznaju kao važan uzrok farmakorezistentne epilepsije. Cilj studije bio je utvrditi epileptogenost MKR korelirajući MRI, EET i simptomatologiju epileptičnih napada, te odrediti povezanost MKR na farmakorezistentnost epilepsije. Također je namjera bila utvrditi korisnost interiktalne pretrage SPECT-a za potvrdu proširenosti MRK i relativnu učestalost različitih tipova MKR. Simptomatologija epileptičnih napada i »elektroklinička epileptogenost« MKR prema nalazu MRI mozga utvrđene su na osnovi interiktalnih nalaza EEG. MRI mozga je otkrila kortikalnu displaziju u devetoro bolesnika, polimikrogiriju u četvoro bolesnika, te lisencefaliju i shizencefaliju u po jednog bolesnika, dok je troje bolesnika imalo kombinaciju različitih malformacija. Lokalizacija hipoperfuzije na SPECT-u odgovarala je oštećenju MKR u desetoro (66,67%) bolesnika. Elektroklinički potvrđena epileptogenost MKR preklapala se s nalazima MRI i interiktalnog SPECT u četrnaestoro (93,3%) odnosno devetoro (60,0%) bolesnika. Naši su nalazi pokazali kako su MKR visoko epileptogena i čest razlog farmakorezistentnosti u bolesnika sa epilepsijom.

    English abstract

    Malformations of cortical development (MCD) have been increasingly recognized as an important cause of intractable epilepsy. The aim of our study was to define epileptogenicity of MCDs by correlating MRI, EEG and semiology of epileptic attacks, and to determine the effect of MCD on drug resistant epilepsy. We also intended to reveal the utility of interictal single photo emission computed tomography (SPECT) in verification of MCD lesions and relative prevalence of different MCDs. Based on interictal EEG finding, semiology of the epileptic attacks and brain magnetic resonance imaging (MRI) "electroclinical epileptogenicity" of MCD was defined. Brain MRI revealed cortical dysplasia (CD) in nine patients, polymicrogyria in four patients, lissencephaly and schizencephaly in one patient each. Three patients had a combination of malformations. The localization of SPECT hypoperfusion corresponded to MCD lesion in ten (66.67%) patients. Electroclinically confirmed epileptogenicity of MCD overlapped with MR and interictal SPECT findings in fourteen (93.3%) and nine (60.0%) patients, respectively. Our study results demonstrated the MCD lesions to be highly epileptogenic and a frequent cause of intractability.

    Item Type: Article
    MeSH: Magnetic Resonance Imaging ; Tomography, Emission-Computed, Single-Photon ; Cerebral Cortex - abnormalities - radionuclide imaging ; Epilepsy - complications - physiopathology ; Adolescent ; Adult ; Electroencephalography ; Female ; Humans ; Male ; Middle Aged ; Organotechnetium Compounds - diagnostic use ; Radiopharmaceuticals - diagnostic use
    Divisions: Katedra za neurologiju
    Depositing User: Boris Čičovački
    Status: Published
    Creators:
    CreatorsEmail
    Sporiš, Davor
    Hajnšek, Sanja
    Boban, Marina
    Bašić, Silvio
    Petrović, Ratimir
    Radoš, Marko
    Babić, Tomislav
    Date: June 2008
    Date Deposited: 04 Nov 2008
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/514

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