Risk factor analysis and diagnoses of coronary heart disease in patients with hypercholesterolemia from Croatian Zagorje County

Pešek, Ksenija and Buković, Damir and Pešek, Tomislav and Orešković, Slavko and Milinović, Darko and Rukavina, Marko and Pavić, Mato and Zlojtro, Marija (2008) Risk factor analysis and diagnoses of coronary heart disease in patients with hypercholesterolemia from Croatian Zagorje County. Collegium Antropologicum, 32 (2). pp. 369-374. ISSN 0350-6134

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Abstract

Our aim is to determine if there exists a difference in risk factors and diagnosis between patients being treated on internal medicine ward for coronary heart disease who have higher levels of cholesterol in their blood and other patients, without proved higher levels of cholesterol, hospitalized for coronary heart disease. We followed patients hospitalized in General Hospital Zabok for coronary heart disease for the period between 2004-2006y. On admission patients were diagnosed with coronary heart disease based on laboratory markers specific for the disease (CK, troponin, LDH,CRP), ECG and history taking. We analyzed two groups of patients for diagnosis and risk factors on discharge from the hospital: one group with proven hypercholesterolemia, the other with coronary heart disease without hypercholesterolemia. For the duration of the study there were no significant alternations concerning risk factors for coronary heart disease, and hypertension was the most prevalent of these factors in both groups. Values of HDL, as an indirect indicator of coronary heart disease, were lower in both groups for the duration of the study. In group of patients with hypercholesterolemia myocardial infarction with a ST segment elevation, as a discharge diagnosis, was a more prevalent complication of the disease, while for the group of patients without hypercholesterolemia stable angina pectoris was more prevalent and this is explained as atheroma plaque stabilization when there are normal values of blood cholesterol.

Abstract in Croatian

Utvrditi da li postoje razlike rizičnih čimbenika i dijagnoze koronarne bolesti srca kod pacijenata sa hiperholesterolemijom prema ostalima, koji su zbog dijagnoze koronarne bolesti srca hospitalizirani na internom odjelu. U periodu od 2004. godine do 2006. godine praćeni su pacijenti hospitalizirani u Općoj bolnici Zabok zbog koronarne bolesti srca. Kod pacijenata se kod prijema profilom markera za koronarnu bolest/CK, troponin, LDH, CRP/, elektrogardiogramom, anamnestičkim podacima utvrđivala dijagnoza koronarne bolesti srca. Po otpustu analizirane su dvije grupe pacijenata po dijagnozama i rizičnim faktorima i to grupa pacijenata koja je imala dokazanu hiperholesterolemiju prema grupi koja nije imala dokazanu hiperholesterolemiju. Tijekom cijelog perioda praćenja nije bilo značajne promjene u profilu rizičnih čimbenika, hipertenzija je tijekom cijelog perioda bila najčešće utvrđeni rizični čimbenik u obje grupe. HDL holesterol kao indirektni pokazatelj rizika koronarne bolesti bio snižen podjednako u obje grupe tijekom cijelog perioda praćenja. U grupi pacijenata sa hiperholesterolemijom češće je kao otpusna dijagnoza utvrđen akutni infarkt miokarda sa elevacijom spojnice dok je kod ostalih stabilna angina pectoris što govori u prilog stabilizacije plaka kod normalnih vrijednosti holesterola prema nestabilnom plaku kod povišenih vrijednosti holesterola.

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