Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia

Tikvica, Ana and Kušan Jukić, Marija and Pintarić, Ivana and Medić, Marijana and Hudiček-Martinčić, Gordana and Košec, Vesna and Salihagić-Kadić, Aida (2008) Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia. Collegium Antropologicum, 32 (2). pp. 565-570. ISSN 0350-6134

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Abstract

In order to study the possible role of nitric oxide (NO) in the human placenta, we measured the concentration of its stable metabolite nitrite (NO2-) in the placentas of women with normal pregnancies and those from pregnancies complicated by intrauterine growth restriction (IUGR) with or without fetal hypoxia. We have measured nitrites by the Griess reaction in 15 placentas from IUGR pregnancies and 12 controls. Cerebroumbilical ratio (C:U) was recorded by color Doppler ultrasound and values below 1 were considered to be a predictor for fetal hypoxia. NO2- levels measured in pathological placentas were increased for at least 93% as compared to control. Subjects from pregnancies complicated by IUGR and fetal hypoxia had increased NO2- as compared to the placentas from pregnancies with IUGR and normal fetal oxygenation. NO production in placenta is increased in pregnancies with IUGR. This effect is more pronounced in those with compromised fetal oxygenation.

Abstract in Croatian

Kako bismo istražili moguću ulogu dušikovog monoksida (NO) u ljudskoj posteljici mjerili smo koncentracije njegovih stabilnih metabolita nitrita (NO2) u posteljicama žena s normalnim trudnoćama, kao i kod onih s fetalnim zastojem u rastu sa ili bez hipoksije. Koncentraciju nitrita određivali smo pomoću Griessove reakcije kod 12 posteljica iz trudnoća kompliciranih zastojem u rastu, te kod 12 kontrola. Cerebroumbilikalni omjer (C/U) određivan je pomoću ultrazvučnog obojenog Dopplera, a njegove vrijednosti manje od 1 smatrane su dobrim pokazateljima fetalne hipoksije. Vrijednosti NO2 – mjerene u posteljicama iz patoloških trudnoća su najmanje za 93 % uvećane u usporedbi s kontrolom. Štoviše, posteljice iz trudnoća s fetalnim zastojem u rastu i fetalnom hipoksijom imaju znatno veće koncentracije NO2 – u usporedbi s posteljicama s fetalnim zastojem u rastu, ali s normalnom fetalnom oksigenacijom. Stvaranje dušikovog monoksida je povećano u posteljicama trudnoća s fetalnim zastojem u rast. Taj je efekt još izraženiji ako je, uz zastoj u rastu, kompromitirana i fetalna oksigenacija.

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