Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Pregnancy outcome after treatment with radioiodine for differentiated thyroid carcinoma

Balenović, Antonija and Vlašić, Marko and Sonicki, Zdenko and Bodor, Davor and Kusić, Zvonko (2006) Pregnancy outcome after treatment with radioiodine for differentiated thyroid carcinoma. Collegium antropologicum, 30 (4). pp. 743-748. ISSN 0350-6134 (Print)

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    Croatian abstract

    Cilj studije bio je utvrditi utjecaj radioaktivnog joda (RAI) na trudnoće, kao i na zdravlje djece bolesnica koje su primale terapijske doze I-131 radi diferenciranog karcinoma štitnjače (DTC). Trudnoće u 76 bolesnica liječenih radi DTC-a u periodu od 1971.–2005. g. su retrospektivno analizirane. Ishod 49 trudnoća koje su uslijedile nakon terapije RAI bio je: 35 djece (72%), 5 spontanih pobačaja (10%) i 9 arteficijalnih pobačaja (18%). Terapija radioaktivnim jodom nije negativno utjecala na stopu uspješnih poroda, niti na demografske osobine novorođenčadi. Kongenitalne malformacije i mortalitet u prvoj godini života nisu registrirani. Srednja dob djece bila je 8 godina (raspon 1 mjesec do 29 godina, SD=8.4). U bolesnica koje su primile veće terapijske doze radioaktivnog joda (>100 mCi) nije registriran lošiji ishod. Bolesnicama liječenim radioaktivnim jodom radi diferenciranog karcinoma štitnjače nije potrebno preporučivati izbjegavanje trudnoće. Preporuča se izbjegavati trudnoću u godini neposredno nakon primanja terapije I-131.

    English abstract

    The aim of the study was to investigate the influence of radioiodine (RAI) therapy on pregnancies and the health status of children born to mothers who had received therapeutic doses of I-131 for differentiated thyroid carcinoma (DTC). Gestational histories of 76 women treated for DTC from 1971-2005 were retrospectively analyzed. The outcome of 49 pregnancies after RAI was: 35 children (72%), 5 (10%) miscarriages and 9 (18%) induced abortions. RAI did not adversely affect the rate of successful delivery and live birth demographics. Congenital malformation and first year mortality were not observed. The children's ages range from 1 month to 29 years (chi+/-SD=8.0+/-8.4). A higher therapeutic dose (>100 mCi) did not significantly alter the pregnancy outcome. There is no reason to discourage females treated with 1-131 from becoming pregnant. Patients should avoid pregnancy after RAI administration for 1 year.

    Item Type: Article
    MeSH: Adenocarcinoma, Follicular - radiotherapy - surgery ; Carcinoma, Papillary - radiotherapy - surgery ; Iodine Radioisotopes - therapeutic use ; Pregnancy Outcome ; Thyroid Neoplasms - radiotherapy ; Adolescent ; Adult ; Combined Modality Therapy ; Female ; Humans ; Infant, Newborn ; Male ; Pregnancy ; Thyroidectomy
    Divisions: Katedra za radiologiju i opću kliničku onkologiju
    Katedra za medicinsku statistiku, epidemiologiju i medicinsku informatiku
    Depositing User: Boris Čičovački
    Status: Published
    Creators:
    CreatorsEmail
    Balenović, Antonija
    Vlašić, Marko
    Sonicki, Zdenko
    Bodor, Davor
    Kusić, Zvonko
    Date: December 2006
    Date Deposited: 20 Oct 2008
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/501

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