Eighteen years of heart transplantation: a single center experience

Ćorić, Vedran and Miličić, Davor and Gašparović, Hrvoje and Rajsman, Gordana and Širić, Franjo and Jelić, Ivan (2006) Eighteen years of heart transplantation: a single center experience. Collegium Antropologicum, 30 (4). pp. 909-913. ISSN 0350-6134

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Abstract

The best option for the treatment of a failing heart is heart transplantation. The transplantation program at the University Hospital Center Rebro Zagreb started in 1988. To the best of our knowledge this is the first retrospective study on cardiac transplantation in Croatia looking into survival following heart transplantation. Between 1988 and 2006, we performed 81 heart transplantations at the University Hospital Center Rebro Zagreb. Our study focused on the last ten years after establishment of the Department of cardiac surgery as a separate institution. There were thirteen different hospitals throughout Croatia, which contributed to the donor network. Average age of the heart recipient was 48+/-11.8 years (range 14-72), and average age of the heart donor was 34+/-10.7 years (range 14-56). There were more women among the heart donors (34%) then among the heart recipients (18%). During the first ten years, from 1988-1998, the average number of cardiac transplantations was 3 per year In the period from 1998-2006, average number of cardiac transplantations increased to 6 per year. The average thirty-day mortality for the last nine years was 27%. It declined from 30% and 40% in 1998 and 1999, respectively down to 0% in the last two years. Average age of the patients who died was 50+/-6.5years (range 44-62) and did not significantly differ from those who survived. The donor network has grown up to fourteen different hospitals throughout Croatia. The limiting factor in cardiac transplant surgery is the number of available donors. Therefore in attempt to form a good transplant program it is crucial to form an efficient donor network. The number of performed cardiac transplantations is expected to rise until it reaches the number of available donors. With advances in operative technique and postoperative management--immunosuppressive therapy we have observed a remarkable drop in the early operative mortality in the studied period.

Abstract in Croatian

Najbolji rezultati u liječenju srčanog zatajenja postižu se transplantacijom srca. Transplantacijski program na Kliničkom Bolničkom Centru Rebro Zagreb započeo je 1988. Prema našim spoznajama ovo je prva retrospektivna studija o transplantaciji srca u Hrvatskoj koja analizira preživljenje nakon transplantacije srca. Između 1988. i 2006. izvedena je 81 transplantacija srca na KBC Zagreb. Naša studija se fokusirala na posljednjih 10 godina nakon formiranja Klinike za kardijalnu kirurgiju kao zasebnog odjela. Trinaest različitih bolnica u Hrvatskoj sačinjava mrežu za donaciju organa. Prosječna dob primaoca bila je 48±11.8 godina (raspon 14–72), a prosječna dob donora bila je 34±10.7 godina (raspon 14–56). Žene su češće bile donori srca (34%), nego primaoci (18%).Tijekom prvih deset godina od 1988–1998 prosječno je bilo tri transplantacije srca godišnje. U razdoblju od 1998–2006 prosječan broj transplantacija srca porastao je na šest transplantacija godišnje. Prosječan 30 dnevni mortalitet za posljednjih devet godina iznosi 27%. Mortalitet je pao s 30% i 40% u 1998 i 1999 godini na 0% u posljednje dvije godine. Prosječna dob umrlih bolesnika iznosila je 50±6.5 godina (raspon 44–62) i nije se statistički razlikovala od dobi preživjelih bolesnika. Mreža bolnica donatora povećala se na četrnaest bolnica diljem zemlje. Transplantacijski programi su limitirani brojem dostupnih donora. Stoga je za formiranje dobrog transplantacijskog programa ključno oformiti učinkovitu donorsku mrežu. Broj transplantacija očekivano raste dok ne dosegne broj dostupnih donora. Napredak u operacijskoj tehnici i poslijeoperacijskom tretmanu – imunosupresivnoj terapiji rezultirao je zamjetnim padom mortaliteta u ranom poslijeoperacijskom razdoblju.

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