Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach

Sabalić, Srećko and Kovačević, Dujo and Glavić, Željko and Buković, Damir and Despot, Albert and Fajdić, Josip and Lukač, Josip and Šešo, Ivana (2006) The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach. Collegium antropologicum, 30 (4). pp. 885-893. ISSN 0350-6134 (Print)

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    Croatian abstract

    Analizirano je 542 bolesnika operiranih zbog kolorektalnog karcinoma radi procijene utjecaja primanja transfuzije na pojavu lokalnih recidiva i na period bez bolesti – preživljavanje. Istražene su promjene u pokazateljima opće imunosti i njihovu moguću povezanost sa perioperacijskom transfuzijom. Nađena je značajna povezanost pojave lokalnih recidiva i primanja transfuzije (p<0,0001), najizraženije kod Dukesa A (p=0,045), lokalizacije na rektumu i rektosigmoidu (p=0,036). Količina transfuzije najviše je povezana sa pojavom lokalnih recidiva kod Dukesa A (p=0,008), lokalizacije na rektumu (p=0,008). Primanje transfuzije (p=0,0123; log rank) značajno je povezano sa skraćenjem perioda bez bolesti – preživljavanje, najznačajnije kod Dukes A stadija (p=0,0123; log rank), te pri lokalizaciji na rektumu (p=0,0231; long rank). Analizom pokazatelja opće imunosti uočena je značajna imunokompromitacija bolesnika prije same operacije, što bi moglo djelovati na stupanj imunomodulacije uzrokovane transfuzijom, a tim i na prognozu liječenja kolorektalnog karcinoma.

    English abstract

    The total number of 542 patients with colorectal cancer surgery have been analyzed in order to estimate the effect of receiving transfusion local recurrences, and the disease free - survival. It should be examined whether there are changes in general immunity indicators which would be connected with perioperative transfusion. A significant connection has been found between local recurrences and blood transfusion (p<0.0001), the most noticeable being in Dukes A (p =0.045), localization on rectum (p=0.036). The receiving of blood transfusion is linked significantly with disease free - survival reduction (p =0.0068; log rank), the most significant being in Dukes A stage (p =0.0123; log rank) and with localization on rectum (p=0.0231). The analysis of general immunity indicators has shown significant immunocompromitation of patients just before the surgery and this could have effect on immunomodulation caused by transfusion and just as on the treatment prognosis of colorectal carcinoma.

    Item Type: Article
    MeSH: Blood Transfusion - adverse effects ; Colorectal Neoplasms - immunology - surgery - therapy ; Immune Tolerance ; Disease-Free Survival ; Humans ; Immunity, Cellular ; Neoplasm Recurrence, Local ; Prognosis
    Divisions: Katedra za ginekologiju i opstetriciju
    Depositing User: Boris Čičovački
    Status: Published
    Creators:
    CreatorsEmail
    Sabalić, Srećko
    Kovačević, Dujo
    Glavić, Željko
    Buković, Damir
    Despot, Albert
    Fajdić, Josip
    Lukač, Josip
    Šešo, Ivana
    Date: December 2006
    Date Deposited: 20 Oct 2008
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/498

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