Incidence of pituitary tumors in the human population of Croatia

Vrkljan, Milan and Matovinović, Martina and Marić, Andreja and Bekić, Marijo and Zah, Tajana and Rešetić, Josip and Vizner, Branka and Pećina, Hrvoje Ivan and Čerina, Vatroslav and Gnjidić, Živko (2006) Incidence of pituitary tumors in the human population of Croatia. Collegium Antropologicum, 30 (1). pp. 157-161. ISSN 0350-6134

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Abstract

Pituitary tumors are rare tumors (less then 10%) of the central nervous system (CNS), which malignicity depends on their localization, meanwhile, their biological nature is benign. The diameter they have is mostly less then 10 mm (microadenomas), but sometimes could be 10 mm (macroadenomas) to 5 cm and more and then are usually nonfunctional (about 20% of all pituitary tumors). Clinical presence depends on their localisation and hormonal activity. In the Center for Clinical Neuroendocrinology and Pituitary Diseases, in the last working 10 years, there were treated and examined 504 patients from Croatia, all with pituitary tumors: 182 patients with prolactinomas, 137 with acromegaly, 70 with Morbus Cushing (Mb. Cushing), and 115 patients with nonfunctional pituitary tumors. The patient's classification is based on regional (Mediterranean and continental region, 20 counties) and the state level. In our analysis we haven't found difference in incidence of tumors between Mediterranean and continental region.

Abstract in Croatian

Tumori hipofize su rijetki tumori središnjeg živčanog sustava (manje od 10%) koji su maligni zbog svoje lokalizacije, dok im je biološka priroda benigna. Obično su manji od 10 milimetara (mikroadenomi), ali nekada su veći od 1 cm (makroadenomi) pa i preko 5 centimetara i tada su obično funkcionalno nijemi (oko 20% svih hipofiznih tumora). Klinička slika ovisi o sijelu tumora i hormonskoj aktivnosti. U Centru za kliničku neuroendokrinologiju i bolesti hipofize Kliničke bolnice »Sestre milosrdnice« u zadnjih 10 godina obrađeno je i liječeno ukupno 504 bolesnika: 182 bolesnika s prolaktinskim tumorom, 137 s akromegalijom, 70 s Cushingovom bolešću te 115 bolesnika s funkcionalnim tumorom hipofize. Svi su bolesnici analizirani po regionalnoj pripadnosti (primorska i kontinentalna regija, 20 županija) i na razini cijele Republike Hrvatske. Obradom nismo utvrdili razlike u učestalosti pojave tumora hipofize između primorske i kontinentalne Hrvatske.

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