Neopterin kinetics after cardiac surgery with or without cardiopulmonary bypass

Brkić, Kristina and Unić, Daniel and Sutlić, Željko and Biočina, Bojan and Rudež, Igor and Barić, Davor and Lukić, Ivan Krešimir (2006) Neopterin kinetics after cardiac surgery with or without cardiopulmonary bypass. Collegium antropologicum, 30 (2). pp. 395-400. ISSN 0350-6134 (Print)

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Abstract

Cardiac surgery (CS) with cardiopulmonary bypass (CPB) induces systemic inflammatory response by activating plasma proteins and blood cells. Activated monocytes/macrophages produce inflammatory marker neopterin (NP). The aim was to explore the NP kinetics in first 24 hours after CS according to the CPB use. Significant difference between groups was found for NP levels 12 and 24 hrs after CS, being higher in on-pump group. Strong association was found between NP levels 12 hrs after CS and the length of ICU stay for on-pump group (r=0.744, p<0.001). Strong association was found between preoperative NP levels and the length of ICU stay for those on-pump patients with elevated preoperative NP (r=0.855, p=0.001; linear regression equation y=0.50x-5.14, p<0.001). Preoperative NP levels higher than 10 nmol/L in on-pump group could predict prolonged ICU stay and outpoint patients at higher risk for developing postoperative complications and, therefore, help to determine the necessary therapeutic interventions.

Item Type: Article
MeSH: Cardiac Surgical Procedures - adverse effects ; Cardiopulmonary Bypass - adverse effects ; Neopterin - blood ; Systemic Inflammatory Response Syndrome - blood - diagnosis - etiology ; Aged ; Analysis of Variance ; Biological Markers - blood ; Female ; Humans ; Length of Stay ; Linear Models ; Male ; Middle Aged
Departments: Katedra za anatomiju i kliničku anatomiju
Katedra za kirurgiju
Depositing User: Boris Čičovački
Status: Published
Creators:
CreatorsEmail
Brkić, KristinaUNSPECIFIED
Unić, DanielUNSPECIFIED
Sutlić, ŽeljkoUNSPECIFIED
Biočina, BojanUNSPECIFIED
Rudež, IgorUNSPECIFIED
Barić, DavorUNSPECIFIED
Lukić, Ivan KrešimirUNSPECIFIED
Date: June 2006
Date Deposited: 15 Oct 2008
Last Modified: 23 Sep 2011 16:10
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/475

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