Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis

Rahelić, Dario and Kujundžić, Milan and Romić, Željko and Brkić, Kristina and Petrovečki, Mladen (2006) Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis. Collegium antropologicum, 30 (3). pp. 523-528. ISSN 0350-6134 (Print)

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    Croatian abstract

    Cilj istraživanja bio je odrediti serumske koncentracije cinka, bakra, mangana i magnezija u bolesnika s jetrenom cirozom i usporediti ih s koncentracijama u zdravih ispitanika. Serumske koncentracije navedenih elemenata u tragovima bile su određivane u 105 bolesnika s jetrenom cirozom i 50 ispitanika kontrolne skupine pomoću plazma sekvencijskog spektrofotometra. Serumske koncentracije cinka bile su statistički značajno niže u bolesnika s jetrenom cirozom u odnosu na ispitanike kontrolne skupine (medijan 0.82 prema 11.22 mol/L, p<0.001). Koncentracije bakra bile su značajno povišene u bolesnika s jetrenom cirozom u odnosu na kontrolnu skupinu (medijan 21.56 prema 13.09 mol/L, p<0.001) kao i koncentracije mangana (medijan 2.50 prema 0.02 mol/L, p<0.001). Koncentracije magnezija nisu bile značajno različite između bolesnika s jetrenom cirozom i ispitanika kontrolne skupine (p=0.132). Koncentracije cinka, bakra, mangana i magnezija nisu bile različite u muških i ženskih bolesnika s jetrenom cirozom. Serumske koncentracije mangana bile su statistički značajno različite između Child-Pughovih skupina (p=0.036), dok koncentracije cinka, bakra i magnezija nisu bile značajno različite između Child-Pughovih skupina. Značajno niže serumske koncentracije cinka pronađene su u bolesnika s jetrenom cirozom i portalnom encefalopatijom u usporedbi s bolesnicima bez portalne encefalopatije (0.54 prema 0.96 mol/L, p=0.002). Korekcija koncentracija elemenata u tragovima mogla bi imati pozitivan učinak na komplikacije a moguće i tijek jetrene ciroze, stoga bi bilo preporučljivo u bolesnika s jetrenom cirozom određivati serumske koncentracije elemenata u tragovima kao dio rutinske laboratorijske obrade.

    English abstract

    The role of trace elements in the pathogenesis of liver cirrhosis and its complications is still not clearly understood. Serum concentrations of zinc, copper, manganese and magnesium were determined in 105 patients with alcoholic liver cirrhosis and 50 healthy subjects by means of plasma sequential spectrophotometer. Serum concentrations of zinc were significantly lower (median 0.82 vs. 11.22 micromol/L, p < 0.001) in patients with liver cirrhosis in comparison to controls. Serum concentrations of copper were significantly higher in patients with liver cirrhosis (median 21.56 vs. 13.09 micromol/L, p < 0.001) as well as manganese (2.50 vs. 0.02 micromol/L, p < 0.001). The concentration of magnesium was not significantly different between patients with liver cirrhosis and controls (0.94 vs. 0.88 mmol/L, p = 0.132). There were no differences in the concentrations of zinc, copper, manganese and magnesium between male and female patients with liver cirrhosis. Only manganese concentration was significantly different between Child-Pugh groups (p = 0.036). Zinc concentration was significantly lower in patients with hepatic encephalopathy in comparison to cirrhotic patients without encephalopathy (0.54 vs. 0.96 micromol/L, p = 0.002). The correction of trace elements concentrations might have a beneficial effect on complications and maybe progression of liver cirrhosis. It would be recommendable to provide analysis of trace elements as a routine.

    Item Type: Article
    MeSH: Liver Cirrhosis, Alcoholic - blood - classification - complications ; Trace Elements - blood ; Ascites - complications ; Case-Control Studies ; Copper - blood ; Female ; Humans ; Magnesium - blood ; Male ; Manganese - blood ; Middle Aged ; Zinc - blood
    Divisions: Katedra za internu medicinu
    Depositing User: Boris Čičovački
    Status: Published
    Creators:
    CreatorsEmail
    Rahelić, Dario
    Kujundžić, Milan
    Romić, Željko
    Brkić, Kristina
    Petrovečki, Mladen
    Date: September 2006
    Date Deposited: 14 Oct 2008
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/470

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