The place and role of serologic methods in detecting Helicobacter pylori infection

Marušić, Marinko and Presečki, Vladimir and Katičić, Miroslava and Dominis, Mara and Kalenić, Smilja (2006) The place and role of serologic methods in detecting Helicobacter pylori infection. Collegium Antropologicum, 30 (3). pp. 529-533. ISSN 0350-6134

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Abstract

The aim of the study was to determine the place and role of serologic methods in detecting Helicobacter pylori (H. pylori) infection, on the basis of estimated enzyme-linked immunosorbent assay (ELISA) and complement fixation test (CFT) sensitivity and specificity. A total of 549 patients were included in the study. ELISA and CFT as serologic methods were compared with invasive methods (rapid urease test--CLO test, culture, histology). The sensitivity of serologic methods was above 90%, and their specificity was around 80%. Study results confirmed the value, reliability and usefulness of serologic methods in the detection of H. pylori infection.

Abstract in Croatian

Cilj nam je bio na temelju utvrđenih vrijednosti osjetljivosti i specifičnosti metoda ELISA (imunoenzimski test) i reakcije vezanja komplementa odrediti mjesto i značenje seroloških metoda u otkrivanju infekcije Helicobacter pylori (H. pylori). U ispitivanje je bilo uključeno 549 bolesnika, a navedene serološke metode su uspoređene s invazivnim metodama (CLO test, izolacija, histološki pregled). Osjetljivost seroloških metoda premašila je 90%, dok je specifičnost bila približno 80%. Ovim radom je dokazana vrijednost, pouzdanost i opravdanost uporabe seroloških postupaka u otkrivanju infekcije H. pylori.

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