Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

DNA methylation as a regulatory mechanism for gene expression in mammals

Šerman, Alan and Vlahović, Maja and Šerman, Ljiljana and Bulić-Jakuš, Floriana (2006) DNA methylation as a regulatory mechanism for gene expression in mammals. Collegium antropologicum, 30 (3). pp. 665-671. ISSN 0350-6134 (Print)

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    Croatian abstract

    Nasljedne promjene u ekspresiji gena koje se nasljeđuju neovisno o promjenama slijeda baza u molekuli DNA definiraju pojam epigenetike. Zadnja dekada, pokazala je da epigenetski mehanizmi omogućavaju dodatnu regulaciju ekspresije gena na razini transkripcije. Tri sistema, uključujući metilaciju DNA, modifikaciju histona i RNA-posredovano djelovanje, danas se povezuju s regulacijom ekspresije gena. Oni su kritični regulatori kako embrionalnog razvoja tako i samog rasta stanica. Proces metilacije molekule DNA predstavlja epigenetski mehanizam uključen u inaktivaciju transkripcije gena, genomski imprinting, osigurava neaktivnost većine gena na inaktivnom X kromosomu u stanicama ženskog organizma kao i tumor supresor gena u raku. Ovim pregledom iznjeli smo osnovne principe metilacije DNA molekule kao glavnog epigenetskog mehanizma regulacije genske ekspresije, s težištem na njezinoj ulozi u normalnom embrionalnom razvoju te poremećajima koji dovode do razvoja raka.

    English abstract

    Epigenetics refers to the study of heritable changes in gene expression that occur without a change in DNA sequence. In the last decade, it has been shown that epigenetic mechanisms provide an "extra" layer of transcriptional control that regulates genes expression. Three distinct mechanisms appear intricately related in initiating and sustaining epigenetic modifications: RNA-associated silencing, DNA methylation and histone modification. These mechanisms are critical components in the normal development and cell growth. DNA methylation is involved in transcriptional silencing of genes, regulation of expression of imprinted genes, a number of tumour suppressor genes in cancer and silencing of genes located on the inactive X chromosome. In this review, we are focused on the basic principles of DNA methylation as the main epigenetic mechanism for normal embryonic development and epigenetic alterations that contribute to carcinogenesis.

    Item Type: Article
    MeSH: DNA Methylation ; Epigenesis, Genetic - genetics - physiology ; Gene Expression Regulation - genetics - physiology ; Gene Silencing - physiology ; Genomic Imprinting - physiology ; Animals ; Female ; Humans ; Male ; Mammals
    Divisions: Katedra za medicinsku biologiju
    Depositing User: Boris Čičovački
    Status: Published
    Creators:
    CreatorsEmail
    Šerman, Alan
    Vlahović, Maja
    Šerman, Ljiljana
    Bulić-Jakuš, Floriana
    Date: September 2006
    Date Deposited: 14 Oct 2008
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/466

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