Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease

Bergman Marković, Biserka and Bergovec, Mijo and Reiner, Željko and Sertić, Jadranka and Vincelj, Josip and Marković, Maja (2007) Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease. Collegium Antropologicum, 31 (1). pp. 179-183. ISSN 0350-6134

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Abstract

Controversy exists as to whether the deletion/deletion (DD) genotype of angiotensin l-converting enzyme (ACE) gene polymorphism is associated with coronary heart disease (CHD). There are only a few studies dealing with this issue in the elderly, also with controversial results. The aim of this study was the assessment of correlation between genetic markers and the risk of CHD in the elderly. The results indicated DD genotype importance for CHD in the elderly as proven by discriminant analysis (chi2 = 25.77; df = 16; p = 0.0620). However, the use of univariate method demonstrated no correlation between DD genotype of ACE gene polymorphism and coronary artery disease. D allele of ACE gene was associated with higher activities of ACE plasma. A weak, but increased risk of MI is associated with high frequency of DD genotype in the elderly. Strong correlation between ACE polymorphism and ACE plasma activities was demonstrated.

Abstract in Croatian

Povezanost delecijskog alela (DD genotip) angiotenzin konvertirajućeg enzima (ACE) sa koronarnom bolesti srca (KBS) je dvojbena. Malo je studija posvećeno tom problemu za stariju životnu dob, čiji rezultati su također dvojbeni. Cilj ovog rada je bio procijeniti povezanosti genetskih markera i rizika za KBS u starosti. Rezultati pokazuju da DD genotip ima prediktivnu vrijednost za KBS u starosti prikazano diskriminacijskom analizom (c2=25,77; df=16; P=0.0620). Međutim upotrebljavajući univarijatnu metodu povezanost DD genotipa i KBS nije dokazana. Vrijednost aktivnosti plazmatskog ACE u direktnoj je povezanosti s delecijskim polimorfizmom ACE gena. Zaključak: Povezanost DD genotipa i rizika za KBS u starijoj životnoj dobi također postoji. Prikazana je jaka povezanost ACE polimorfizma i vrijednosti aktivnosti plazmatskog ACE.

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