Regeneration of the skeleton by recombinant human bone morphogenetic proteins

Smoljanović, Tomislav and Grgurević, Lovorka and Jelić, Mislav and Kreszinger, Mario and Hašpl, Miroslav and Matičić, Dražen and Vukičević, Slobodan and Pećina, Marko (2007) Regeneration of the skeleton by recombinant human bone morphogenetic proteins. Collegium Antropologicum, 31 (3). pp. 923-932. ISSN 0350-6134

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Abstract

Recombinant human bone morphogenetic proteins (rhBMPs) have past a long journey in human orthopaedic surgery during the last 15 years. From the first reports of the use of rhBMPs in hostile environments such as critically-sized bone defects, avascular femoral head necrosis, unstable thoracolumbar vertebral fractures, instability between the atlas and axis due to rheumatoid arthritis; over the use for nonunions of long bones and the scaphoid, reconstructive and revision surgeries of the hip, acute fractures, allograft nonunions, congenital pseudarthrosis, and various approaches of lumbar and cervical spine fusions, rhBMPs overgrow to a safe and reliable device in the treatment of open tibial shaft fractures, nonunions of long bone fractures, anterior lumbar interbody fusion and revision posterolateral lumbar fusions. Systematic review of the published literature of rhBMPs is presented.

Abstract in Croatian

Rekombinirani ljudski koštani morfogenetski proteini (recombinant human Bone Morphogenetic Proteins, rhBMP) su prešli dug put tijekom posljednjih 15 godina primjene u ljudskoj ortopediji. Od prvih izviješća o primjeni rhBMP-a u »neprijateljskim« uvjetima kao što su kritični koštani defekti, avaskularne nekroze glave bedrene kosti, nestabilni torakolumbarni prijelomi kralješaka, nestabilnosti između atlasa i aksisa kao posljedica reumatskog artritisa; preko korištenja kod pseudartroza dugih kostiju i skafoida, rekonstruktivnih i revizijskih operacija kuka, akutnih prijeloma, pseudartoza koštanih alogeničnih presadaka, kongenitalnih pseudartroza, te svih poznatih pristupa fuziji vratne i lumbalne kralježnice, rhBMP-ovi su se razvili do sigurnog i pouzdanog sredstva u liječenju otvorenih prijeloma tibije, pseudartroza dugih kostiju, prednje interkorporalne fuzije lumbalnih kralježaka i revizijskih posterolateralnih fuzija lumalne kralježnice. Prikazujemo sistematičan pregled objavljene literature o rhBMP-u.

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