Atherosclerotic lesions of supra-aortic arteries in diabetic patients

Vidjak, Vinko and Hebrang, Andrija and Brkljačić, Boris and Brajša, Mladen and Novačić, Karlo and Barada, Ante and Škopljanac, Andrija and Erdelez, Lidija and Crnčević, Maja and Kučan, Damir and Flegar-Meštrić, Zlata and Vrhovski-Hebrang, Danijela and Roić, Goran (2007) Atherosclerotic lesions of supra-aortic arteries in diabetic patients. Collegium Antropologicum, 31 (3). pp. 723-732. ISSN 0350-6134

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Abstract

The aim of this prospective study was to determine the prevalence and localization of stenotic atherosclerotic lesions of supra-aortic arteries in diabetic patients according to age and sex. Angiograms obtained by digital subtraction angiography were analyzed in 150 diabetic patients (study group) and 150 non-diabetic patients (control group) with symptoms of cerebral ischemia. Diabetic patients were found to have a significantly higher prevalence of stenotic atherosclerotic lesions of the internal carotid artery. Lesions of the large supra-aortic arteries were significantly more common in the left than in the right side of the neck (p < 0.001), but the difference between the diabetic and the non-diabetic group did not reach statistical significance. Hemodynamic conditions were found to be more important than diabetes for the occurrence of atherosclerotic lesions in these arteries. Changes in the proximal segment of the left common carotid artery were the most common finding in diabetic patients, hence attention should be paid to this localization on control examinations.

Abstract in Croatian

Cilj ovog prospektivnog istraživanja bio je odrediti prevalenciju i lokalizaciju stenotičnih aterosklerotskih lezija supraaortnih arterija u bolesnika sa šećernom bolešću prema dobi i spolu. Analizirani su angiogrami dobiveni digitalnom suptrakcijskom angiografijom u 150 bolesnika sa šećernom bolešću (ispitivana skupina) i 150 bolesnika bez šećerne bolesti (kontrolna skupina) sa simptomima cerebralne ishemije. Ustanovljeno je da bolesnici sa šećernom bolešću imaju značajno višu prevalenciju stenotičnih aterosklerotskih lezija unutarnje karotidne arterije. Lezije velikih supraaortnih arterija bile su češće na lijevoj nego na desnoj strani vrata (p<0,001), međutim razlika između dijabetičke i nedijabetičke skupine nije bila statistički značajna. Hemodinamika je imala značajniju ulogu od šećerne bolesti u stvaranju aterosklerotskih lezija ovih arterija. Budući da su kod bolesnika sa šećernom bolešću najčešći nalaz bile promjene proksimalnog segmenta lijeve zajedničke karotidne arterije, pri kontrolnim pregledima trebalo bi posvetiti pozornost toj lokalizaciji.

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