Rice policosanol does not have any effects on blood coagulation factors in hypercholesterolemic patients

Reiner, Željko and Tedeschi-Reiner, Eugenia (2007) Rice policosanol does not have any effects on blood coagulation factors in hypercholesterolemic patients. Collegium Antropologicum, 31 (4). pp. 1061-1064. ISSN 0350-6134

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Abstract

Policosanol is an agent that includes mixtures of aliphatic primary alcohols extracted primarily from sugercane wax. Policosanol has been shown to lower total and LDL cholesterol in animal models, healthy volunteers and hypercholesterolemic patients. However, these findings have been challanged recently. Up to now, there has been no study investigating the effects ofpolicosanol on blood coagulation factors. This study investigated the effects of rice policosanol (Oryza sp.) 10 mg/day on blood coagulation factors in 66 hypercholesterolemic patients of both sexes aged 20 to 78 years in a single center, randomized, double-blind, placebo-controlled, crossover trial. After an 8-week run-in period in which patients were placed on therapeutic lifestyle changes, in particular a cholesterol-lowering diet, they were randomly assigned to receive rice policosanol 10 mg tablets or placebo tablets once daily with the evening meal for 8 weeks. During next 8 weeks those receiving policosanol during the first 8 weeks, received placebo and those taking placebo during the first 8 weeks, received policosanol. Plasma fibrinogen, factors VII, VIII, XII and XIII were measured before and after the treatment. Rice policosanol treatment did not change significantly neither fibrinogen nor factors VII, VIII, XII and XIII.

Abstract in Croatian

Polikozanol je mješavina alifatskih primarnih alkohola koja se poglavito ekstrahira iz šećerne trske. Pokazano je da polikozanol smanjuje ukupni i LDL kolesterol u pokusnih životinja, zdravih dragovoljaca i bolesnika s hiperkolesterolemijom. Međutim, nedavno je to dovedeno pod znak sumnje. Do danas još nije načinjeno istraživanje u kojem bi se ispitali učinci polikozanola na čimbenike zgrušavanja. U ovom su istraživanju ispitani učinci polikozanola iz riže (Oryza sp.) u dozi od 10 mg/dan na čimbenike zgrušavanja u 66 bolesnika oba spola s hiperkolesterolemijom starih između 20 i 78 godina. To je randomizirano, dvostruko slijepo, placebom kontrolirano, križno ispitivanje provedeno u jednom centru. Nakon razdoblja od 8 tjedana tijekom kojih su se bolesnici pridržavali promijenjenog načina života, poglavito dijete za snižavanje kolesterola u krvi, randomizirani su da uzimaju kapsule sa 10 mg polikozanola ili placeba jednom dnevno uz večernji obrok tijekom 8 tjedana. Tijekom slijedećih 8 tjedana oni koji su prvih 8 tjedana uzimali polikozanol, uzimali su placebo i obratno, oni koji su prvih 8 tjedana dobivali placebo, uzimali su polikozanol. Prije i nakon liječenja određivani su im fibrinogen, te čimbenici zgrušavanja VII,VIII, XII i XIII u plazmi. Uzmanje polikozanola iz riže nije uzrokovalo nikakve značajnije promjene ni fibrinogena ni čimbenika VII,VIII, XII i XIII.

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