Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Adjuvant therapy after radical surgery of cervical cancer: Zagreb experience

Kukura, Vladimir and Ciglar, Srećko and Markulin-Grgić, Lijerka and Šantek, Fedor (2007) Adjuvant therapy after radical surgery of cervical cancer: Zagreb experience. Collegium antropologicum, 31 (Suppl.). pp. 155-158. ISSN 0350-6134 (Print)

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    Croatian abstract

    Prikazani su rezultati analize naše studije liječenja 72 bolesnice s rakom vrata maternice. Sedamdeset i dvije pacijentice s IB1 stadijem raka vrata maternice podvrgnute su radikalnoj histerektomiji i zdjeličnoj limfadenektomiji. Skupinu niskog rizika čine bolesnice bez nepovoljnih prognostičkih čimbenika i liječene su samo operacijom. Skupinu visokog rizika tvore žene s presadnicama u zdjeličnim limfnim čvorovima, veličinom tumora preko 3,0 cm, dubinom invazije strome većom od 1/3, nezrelim tumor ima i nazočnošću tumora u limfo-vaskularnim prostorima. Visoko rizične bolesnice primile su zračenje izvana na zdjelicu između dva i četiri tjedna nakon operacije. Trideset četiri bolesnice (47,2%) bile su niskog rizika, a trideset i osam (52,8%) ih je bilo visokog rizika. Lokalni recidiv bolesti je dijagnosticiran u tri slučaja (8,8%) u operiranoj skupini i u četiri bolesnice (10,5%) koje su određene za radioterapiju. Incidencija udaljenih metastaza bila je 2,9% u operiranoj skupini i 5,3% u operiranoj i zračenoj skupini. Petogodišnje preživljenje je bilo 91,2% u skupini bolesnica s niskim rizikom, dok je u skupini bolesnica s visokim rizikom bilo 89,5%. Petogodišnje preživljenje, lokalne i udaljene metastaze bile su slične u bolesnica s niskim i visokim rizikom. Ovo ističe vrijednost zračenja zdjelice u bolesnica s jednim ili više nepovoljnih prognostičkih čimbenika nakon radikalne operacije IB1 stadija raka vrata maternice.

    English abstract

    The results of the analysis of the treatment of 72 patients with carcinoma of the uterine cervix are presented. Seventy-two patients with Stage IB1 carcinoma of the cervix underwent a radical hysterectomy and pelvic lymphadenectomy. The low-risk group includes the patients without unfavourable prognostic factors that were treated by surgery alone. The high-risk group included women with pelvic node metastases, clinical tumour size greater than 3.0 cm, depth of stromal invasion greater than 1/3 of the cervical wall, Grade 3 tumours and the presence of lympho-vascular space involvement. High-risk patients received whole pelvic radiotherapy between two and four weeks following surgery. Thirty-four patients (47.2%) were in the low-risk group and thirty-eight patients (52.8%) were in the high-risk group. Locoregional recurrences were diagnosed in three cases (8.8%) in the surgery group and in four patients (10.5 %) assigned to postoperative radiotherapy. The incidence of distant metastases was 2.9% in the group treated by surgery alone and 5.3% in the group treated by surgery and radiotherapy. Overall survival at five years was 91.2% in the low-risk group and 89.5% in the high-risk group of patients. Five-year overall survival, locoregional and distant metastases were similar in the low-risk and high-risk groups of patients, which emphasizes the value of whole pelvic radiation in patients with one or more unfavourable prognostic factors after radical surgery in Stage IB1 cervical cancer.

    Item Type: Article
    MeSH: Uterine Cervical Neoplasms - drug therapy - pathology - surgery ; Adult ; Chemotherapy, Adjuvant ; Croatia ; Female ; Humans ; Middle Aged ; Postoperative Care ; Risk Factors
    Divisions: Katedra za ginekologiju i opstetriciju
    Katedra za radiologiju i opću kliničku onkologiju
    Depositing User: Boris Čičovački
    Status: Published
    Creators:
    CreatorsEmail
    Kukura, Vladimir
    Ciglar, Srećko
    Markulin-Grgić, Lijerka
    Šantek, Fedor
    Date: April 2007
    Date Deposited: 03 Oct 2008
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/409

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