Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Genital human papillomavirus infection in women from the Zagreb region

Marijan, Tatjana and Vraneš, Jasmina and Mlinarić-Džepina, Ana and Leskovar, Vladimira and Knežević, Jasna and Kvaternik, Matea (2007) Genital human papillomavirus infection in women from the Zagreb region. Collegium antropologicum, 31 (Suppl.). pp. 83-87. ISSN 0350-6134 (Print)

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    Croatian abstract

    Infekcija humanim papilomavirusima (HPV) najčešća je spolno prenosiva bolest, poglavito u mladih, seksualno aktivnih osoba. Kako ustrajna infekcija može dovesti do raka vrata maternice, testiranje na HPV je korisno sredstvo u probiranju žena koje su pod povećanim rizikom od razvoja karcinoma vrata maternice. Cilj ovoga rada bio je utvrditi prevalenciju infekcije HPV visokog rizika (hrHPV, engl. high risk HPV) u različitim dobnim skupinama citološki odabranih žena sa zagrebačkog područja, te analizirati učestalost i rezultate ponovljenih testiranja na hrHPV. U promatranom jednogodišnjem razdoblju (studeni 2005. do studeni 2006.) ukupno je zaprimljeno 3.440 uzoraka obrisaka vrata maternice žena iz ginekoloških ambulanata domova zdravlja i privatnih ginekoloških ordinacija. Uzorci su testirani na prisutnost 13 genotipova hrHPV testom AMPLICOR HPV (Roche Molecular Systems), koji se temelji na lančanoj reakciji polimerazom. Ukupna prevalencija hrHPV iznosila je 34,6%. Većina uzoraka zaprimljena je od žena u dobnoj skupini od 21–30 godina (44,2%), a slijedile su dobne skupine žena od 31–40 (27,6%), 41–50 (15,7%), 51–60 (5,3%) i ≥61 godine (2,4%). Od ukupno 3.227 obrisaka vrata maternice zaprimljenih od žena poznate dobi 4,9% je otpadalo na populaciju djevojaka mlađih od 21 godine. U toj dobnoj skupini utvrđena je najveća prevalencija infekcije hrHPV (49,4%). Slična prevalencija uočena je u žena dobne skupine od 21–30 godina (45,1%). U starijim dobnim skupinama prevalencija se postupno smanjivala. U promatranom razdoblju testiranje na hrHPV ponovljeno je u različitim vremenskim razmacima na uzorcima dobivenim od 66 žena. Od 28 žena koje su na prvom testiranju bile negativne samo ih je pet bilo pozitivno na ponovnom testiranju. Od 38 žena koje su na prvom testiranju bile pozitivne u jedne trećine se hrHPV se nije mogao utvrditi kod ponovnog testiranja. Kako se je očekivalo, infekcija hrHPV najučestalija je u adolescentica i mladih žena. Potrebna su daljnja istraživanja o ponavljanim hrHPV testiranjima kako bi se mogla procijeniti stopa iščezavanja virusa i stopa novo stečenih infekcija.

    English abstract

    Human papillomavirus (HPV) infection is the most common sexually transmitted infection, especially among young, sexually active individuals. As persistent infection with oncogenic types may lead to cervical cancer, HPV testing is a useful tool to screen for women at risk for subsequent development of cervical cancer. The aim of the study was to determine the prevalence of high-risk HPV (hrHPV) infection in different age groups of cytologically selected women from the Zagreb region, and to evaluate the frequency and results of repeat hrHPV testing. During a one-year study period (November 2005 to November 2006), a total of 3,440 cervical samples from women attending gynecological services of public and private health care systems were received. They were tested for 13 hrHPV genotypes by the polymerase chain reaction based AMPLICOR HPV test (Roche Molecular Systems). The overall prevalence of hrHPV was 34.6%. Most samples were obtained from women aged 21-30 years (44.2%), followed by the 31-40 (27.6%), 41-50 (15.7%), 51-60 (5.3%) and 261 (2.4%) age groups. Out of 3,227 cervical samples obtained from women of known age, 4.9% were obtained from the group of girls younger than 21, in which the highest prevalence of hrHPV (49.4%) was found. A similar prevalence was observed in women aged 21-30 (45.1%). The prevalence gradually decreased with age. During the study period, repeat hrHPV testing was performed in samples from 66 women at different intervals. Out of 28 women that were hrHPV negative on initial testing, only five women turned positive on repeat testing. Out of 38 women that were positive on initial testing, in one-third hrHPV could not be detected on repeat testing. As expected, hrHPV infection was highly prevalent in female adolescents and young women. Further investigation on repeat hrHPV testing is needed to assess virus clearance and rate of newly acquired infection.

    Item Type: Article
    MeSH: DNA, Viral - classification - genetics - isolation & purification ; Papillomavirus Infections - complications - diagnosis - epidemiology ; Adult ; Age Distribution ; Croatia - epidemiology ; Female ; Humans ; Middle Aged ; Prevalence ; Uterine Cervical Neoplasms - etiology
    Divisions: Katedra za bakteriologiju, virologiju i parasitologiju
    Depositing User: Boris Čičovački
    Status: Published
    Creators:
    CreatorsEmail
    Marijan, Tatjana
    Vraneš, Jasmina
    Mlinarić-Džepina, Ana
    Leskovar, Vladimira
    Knežević, Jasna
    Kvaternik, Matea
    Date: April 2007
    Date Deposited: 03 Oct 2008
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/408

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