Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels

Bulat, Marin and Lupret, Veljko and Orešković, Darko and Klarica, Marijan (2008) Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels. Collegium Antropologicum, 32 (Suppl.). pp. 43-50. ISSN 0350-6134

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Abstract

It is generally accepted that volume of cerebrospinal fluid (CSF) is secreted in brain ventricles and flows to subarachnoid space to be absorbed into dural venous sinuses or/and into lymphatics via perineural sheats of cranial nerves. Since 99% of CSF volume is water, in experiments on cats 3H-water was slowly infused into lateral ventricle and found that it does not flow to subarachnoid space but that it is rapidly absorbed transventricularly into periventricular capillaries. When 3H-water was infused in cortical subarachnoid space, it was absorbed locally into cerebral capillaries via pia mater. On the contrary, when macromolecule 3H-inulin is applied in CSF it is very slowly eliminated in bloodstream, and, with time, is carried by systolic-diastolic pulsations and mixing of CSF bidirectionally along CSF system. Thus, CSF volume (water) is absorbed rapidly into adjacent cerebral capillaries while inulin is distributed bidirectionally due to its long residence time in CSF Previously, the macromolecules have been used to study CSF volume hydrodynamics and with this misconception of CSF physiology arose.

Abstract in Croatian

Općenito se smatra da se volumen cerebrospinalnog likvora secernira u moždanim komorama i teče u subarahnoidni prostor, te se apsorbira u duralne venske sinuse ili/i u limfu putem perivaskularnih ovojnica kranijskih živaca. Budući da voda sačinjava 99% volumena likvora, u pokusima na mačkama sporo je infundirana 3H-voda u lateralne moždane komore, te je pokazano da ona ne teče u subarahnoidni prostor nego biva brzo apsorbirana u priležeće periventrikularne krvne kapilare. Kada je 3H-voda bila infundirana u kortikalni subarahnoidni prostor ona je kroz piju mater bila apsorbirana lokalno u priležeće cerebralne kapilare. Nasuprot tome, kada je 3H-inulin bio infundiran u likvorske prostore, ta je makromolekula bila veoma sporo odstranjivana u krv, te je tijekom vremena bila raznesena dvosmjerno uzduž likvorskog sustava uslijed sistoličko-dijastoličkih, naprijed-natrag pulzacija likvora i njegova miješanja. Dakle, volumen likvora (voda) se brzo apsorbira lokalno u priležeće moždane kapilare, dok makromolekule (inulin) bivaju dvosmjerno raznesene zbog dugotrajnog boravka u likvoru. Do sada su makromolekule bile korištene za izučavanje hidrodinamike likvora, što je dovelo do krivog shvaćanja fiziologije likvora.

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