Serum cholesterol concentrations in suicidal and non-suicidal male patients suffering from persistent delusional disorder

Marčinko, Darko and Marčinko, Anita and Lončar, Mladen and Jakovljević, Miro and Đorđević, Veljko and Gregurek, Rudolf and Henigsberg, Neven and Folnegović Grošić, Petra and Folnegović-Šmalc, Vera (2008) Serum cholesterol concentrations in suicidal and non-suicidal male patients suffering from persistent delusional disorder. Collegium Antropologicum, 32 (S. 1). pp. 113-117. ISSN 0350-6134

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Abstract

Suicidal behavior is a major health risk in psychiatric disorders, especially in affective and psychotic disorders. The neurobiology of suicidal behavior is still unclear. Suicidality has been related to a reduced cholesterol levels. The aim of this study was to evaluate serum cholesterol concentrations in suicidal and non-suicidal men suffering from persistent delusional disorder and in healthy volunteers. Results showed that serum cholesterol concentrations were significantly lower in suicidal than in non-suicidal patients and healthy controls. Also, level of psychopathology (measured by Brief Psychiatric Rating Scale) is significantly marked in the group of suicidal patients, which indicates the importance of detecting some clinical symptoms in patients with persistent delusional disorder in order to prevent suicidal behavior.

Abstract in Croatian

Suicidalno ponašanje jedan je od vodećih zdravstvenih rizika u psihijatrijskih bolesnika, posebno u afektivnim i psihotičnim poremećajima. Neurobiologija suicidalnog ponašanja još uvijek nije dovoljno objašnjena. Suicidalnost se povezuje sa smanjenom razinom kolesterola. Svrha ovog istraživanja bila je evaluirati serumske koncentracije kolesterola u skupini muških suicidalnih i nesuicidalnih bolesnika s perzistirajućim sumanutim poremećajem te u skupini muških zdravih kontrolnih ispitanika. Rezultati pokazuju kako kod suicidalnih bolesnika postoji značajno niža razina kolesterola nego u skupini nesuicidalnih bolesnika i zdravih kontrolnih ispitanika. Također, razina psihopatologije (na skali BPSR) značajno je naglašenija u skupini suicidalnih bolesnika, što ukazuje na važnost prepoznavanja pojedinih kliničkih simptoma u bolesnika s perzistirajućim sumanutim poremećajem zbog prevencije suicidalnog ponašanja.

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