Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features

Mimica, Ninoslav and Mück-Šeler, Dorotea and Pivac, Nela and Mustapić, Maja and Deželjin, Martina and Stipčević, Tamara and Presečki, Paola and Radonić, Elizabeta and Folnegović-Šmalc, Vera (2008) Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features. Collegium antropologicum, 32 (Suppl.). pp. 119-122. ISSN 0350-6134 (Print)

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Croatian abstract

Post mortem istraživanja su pokazala promjene serotoninskog i kateholaminskog sustava u mozgu oboljelih od Alzheimerove bolesti (AB). Cilj istraživanja bio je odrediti koncentraciju trombocitnog serotonina (5-HT) i aktivnost trombocitne monoaminooksidaze tipa B (MAO-B) u bolesnika s AB sa ili bez psihotičnih simptoma i u skupini zdravih osoba. Dijagnoza vjerojatne AB (NINCDS-ADRDA kriterij) postavljena je u skladu s DSM-IV kriterijima. Za procjenu kognitivnog oštećenja korištena je Mini Mental Status Examination, a za određivanje psihotičnih simptoma Neuropsychiatric Inventory. U trombocitima 116 zdravih osoba (51 muškarac, 65 žena), 70 bolesnika (10 muškaraca, 60 žena) sa psihotičkim simptomima i 151 bolesnika (32 muškarca, 119 žena) bez psihotičkih simptoma određena je koncentracija 5-HT i aktivnost MAO-B pomoću spektrofluorimetrijskih metoda. Koncentracija trombocitnog 5-HT bila je značajno snižena u bolesnica sa psihotičkim i nepsihotičkim simptomima te u nepsihotičkih bolesnika u odnosu na koncentraciju trombocitnog 5-HT u odgovarajućoj skupini zdravih žena i muškaraca. Aktivnost trombocitne MAO-B bila je povećana u muških i ženskih nepsihotičkih bolesnika s AB u usporedbi s aktivnošću u zdravoj kontroli odgovarajućeg spola. U trombocitima nepsihotičkih ženskih bolesnica pronađena je značajno povećana aktivnost MAO-B u odnosu na aktivnost enzima u trombocitima bolesnica sa psihotičkim simptomima. Rezultati istraživanja upućuju da bi aktivnost trombocitne MAO-B mogla biti biokemijski pokazatelj za razlikovanje psihotičkog i nepsihotičkog oblika AB.

English abstract

Post mortem brain studies indicate that alterations in serotonergic and catecholaminergic systems might be associated with Alzheimer's disease (AD). The aim of the study was to determine serotonin (5-HT) levels and monoamine oxidase type B (MAO-B) activity in platelets of psychotic and non-psychotic patients with AD, established according to the NINCDS-ADRDA and DSM-IV-TR criteria. Cognitive impairment and psychotic features were evaluated using Mini Mental Status Examination and Neuropsychiatric Inventory. Platelet 5-HT concentration and MAO-B activity were determined spectrofluorimetrically in 116 (51 male, 65 female) healthy subjects and 70 psychotic (10 male, 60 female) and 151 non-psychotic (32 male, 119 female) patients. Psychotic and non-psychotic female and psychotic male patients had significantly lower platelet 5-HT concentration than corresponding sex matched control subjects. Platelet MAO-B activity was significantly increased in both male and female non-psychotic patients compared to the sex matched controls. Non-psychotic female patients had significantly higher platelet MAO-B activity than psychotic female patients. Our data suggest that platelet MAO-B activity, but not platelet 5-HT concentration, could differentiate between psychotic and non-psychotic subtypes of AD.

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