Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features

Mimica, Ninoslav and Mück-Šeler, Dorotea and Pivac, Nela and Mustapić, Maja and Deželjin, Martina and Stipčević, Tamara and Presečki, Paola and Radonić, Elizabeta and Folnegović-Šmalc, Vera (2008) Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features. Collegium Antropologicum, 32 (S. 1). pp. 119-122. ISSN 0350-6134

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Abstract

Post mortem brain studies indicate that alterations in serotonergic and catecholaminergic systems might be associated with Alzheimer's disease (AD). The aim of the study was to determine serotonin (5-HT) levels and monoamine oxidase type B (MAO-B) activity in platelets of psychotic and non-psychotic patients with AD, established according to the NINCDS-ADRDA and DSM-IV-TR criteria. Cognitive impairment and psychotic features were evaluated using Mini Mental Status Examination and Neuropsychiatric Inventory. Platelet 5-HT concentration and MAO-B activity were determined spectrofluorimetrically in 116 (51 male, 65 female) healthy subjects and 70 psychotic (10 male, 60 female) and 151 non-psychotic (32 male, 119 female) patients. Psychotic and non-psychotic female and psychotic male patients had significantly lower platelet 5-HT concentration than corresponding sex matched control subjects. Platelet MAO-B activity was significantly increased in both male and female non-psychotic patients compared to the sex matched controls. Non-psychotic female patients had significantly higher platelet MAO-B activity than psychotic female patients. Our data suggest that platelet MAO-B activity, but not platelet 5-HT concentration, could differentiate between psychotic and non-psychotic subtypes of AD.

Abstract in Croatian

Post mortem istraživanja su pokazala promjene serotoninskog i kateholaminskog sustava u mozgu oboljelih od Alzheimerove bolesti (AB). Cilj istraživanja bio je odrediti koncentraciju trombocitnog serotonina (5-HT) i aktivnost trombocitne monoaminooksidaze tipa B (MAO-B) u bolesnika s AB sa ili bez psihotičnih simptoma i u skupini zdravih osoba. Dijagnoza vjerojatne AB (NINCDS-ADRDA kriterij) postavljena je u skladu s DSM-IV kriterijima. Za procjenu kognitivnog oštećenja korištena je Mini Mental Status Examination, a za određivanje psihotičnih simptoma Neuropsychiatric Inventory. U trombocitima 116 zdravih osoba (51 muškarac, 65 žena), 70 bolesnika (10 muškaraca, 60 žena) sa psihotičkim simptomima i 151 bolesnika (32 muškarca, 119 žena) bez psihotičkih simptoma određena je koncentracija 5-HT i aktivnost MAO-B pomoću spektrofluorimetrijskih metoda. Koncentracija trombocitnog 5-HT bila je značajno snižena u bolesnica sa psihotičkim i nepsihotičkim simptomima te u nepsihotičkih bolesnika u odnosu na koncentraciju trombocitnog 5-HT u odgovarajućoj skupini zdravih žena i muškaraca. Aktivnost trombocitne MAO-B bila je povećana u muških i ženskih nepsihotičkih bolesnika s AB u usporedbi s aktivnošću u zdravoj kontroli odgovarajućeg spola. U trombocitima nepsihotičkih ženskih bolesnica pronađena je značajno povećana aktivnost MAO-B u odnosu na aktivnost enzima u trombocitima bolesnica sa psihotičkim simptomima. Rezultati istraživanja upućuju da bi aktivnost trombocitne MAO-B mogla biti biokemijski pokazatelj za razlikovanje psihotičkog i nepsihotičkog oblika AB.

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