Temporal lobe volume in disorders with psychotic features

Radonić, Elizabeta and Henigsberg, Neven and Radoš, Marko and Mimica, Ninoslav and Folnegović-Šmalc, Vera (2008) Temporal lobe volume in disorders with psychotic features. Collegium antropologicum, 32 (Suppl.). pp. 139-142. ISSN 0350-6134 (Print)

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Abstract

Since early neuropathological findings, temporal lobe has been related to the pathophysiology of some disorders with psychotic features. The aim of this study was to compare temporal lobe volumes and asymmetry differences in patients with schizophrenia, schizoaffective and bipolar disorders, disorders that cover the whole psychotic spectrum. Temporal lobe volumes were estimated using high resolution magnetic resonance imaging in 60 subjects, 15 subjects in each patient and one healthy volunteer (control) group. There are no statistically significant differences in temporal lobe volumes among patient and control groups. Comparison of left and right temporal lobes shows that left temporal lobes are smaller than right temporal lobes, however this difference reaches statistical significance only in groups of patients with schizoaffective and bipolar disorders. Overall temporal lobe volume may be less informative in respect to neuropathology of disorders with psychotic features than volumes of specific temporal lobe structures, in particular medial temporal lobe structures.

Abstract in Croatian

Već temeljem ranih neuropatoloških analiza, temporalni režanj povezan je s patofiziološkom podlogom nekih duševnih poremećaja s psihotičnim obilježjima. Cilj ovog istraživanja bio je usporediti volumen temporalnog režnja u pacijenata sa shizofrenijom, shizoafektivnim i bipolarnim poremećajem – poremećajima koji tvore spektar psihotičnih poremećaja. Za mjerenje volumena temporalnog režnja rabljena je metoda oslikavanja mozga magnetskom rezonancijom visoke rezolucije na 60 ispitanika, po 15 u svakoj skupini oboljelih kao i u skupini duševno zdravih dobrovoljaca. Nema statistički značajnih razlika u volumenu temporalnog režnja između skupina oboljelih ispitanika i zdravih dobrovoljaca. Usporedba volumena lijevog i desnog temporalnog režnja pokazuje kako je volumen lijevog manji od volumena desnog temporalnog režnja, no ova je razlika statistički značajna samo u skupinama ispitanika sa shizoafektivnim i bipolarnim poremećajem. Ukupni volumen temporalnog režnja vjerojatno je manje značajan za neuropatološku podlogu poremećaja s psihotičnim obilježjima od volumena specifičnih struktura, posebice struktura medijalnog dijela temporalnog režnja.

Item Type: Article
MeSH: Bipolar Disorder - pathology ; Schizophrenia - pathology ; Temporal Lobe - pathology ; Adult ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged
Departments: Katedra za radiologiju i opću kliničku onkologiju
Katedra za psihijatriju i psihološku medicinu
Depositing User: Boris Čičovački
Status: Published
Creators:
CreatorsEmail
Radonić, ElizabetaUNSPECIFIED
Henigsberg, NevenUNSPECIFIED
Radoš, MarkoUNSPECIFIED
Mimica, NinoslavUNSPECIFIED
Folnegović-Šmalc, VeraUNSPECIFIED
Date: January 2008
Date Deposited: 03 Oct 2008
Last Modified: 23 Sep 2011 16:10
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/396

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