Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients

Tomić, Monika and Galešić, Krešimir and Morović-Vergles, Jadranka and Romić, Željko and Mikulić, Ivanka (2008) The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients. Collegium antropologicum, 32 (1). pp. 93-98. ISSN 0350-6134 (Print)

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    English abstract

    The pathogenesis of renal hypertension has not yet been fully clarified. As the potential role of endothelin-1 (ET-1) and nitric oxide (NO) has been postulated, their concentrations were determined in plasma and urine of diabetic patients. The study included 30 diabetic patients (both IDDM and NIDDM) with initial or advanced diabetic nephropathy (decreased endogenous creatinine clearance, proteinuria) and 20 healthy control subjects. The correlation with blood pressure and other renal function parameters was monitored and compared with the control group. Also, the effect of ACE inhibitors (ACEI) on ET-1 and NO patterns was monitored in correlation with arterial hypertension. In diabetic patients that did not receive ACEI therapy, the increase in plasma ET-1 was associated with both systolic and diastolic blood pressure elevation, whereas in those administered ACEI the increase in plasma ET-1 was associated with a systolic blood pressure decline. In addition, the increase in plasma NO was accompanied by a statistically significant decline of both systolic and diastolic blood pressure in diabetic patients receiving ACEI.

    Item Type: Article
    MeSH: Diabetic Nephropathies - metabolism - physiopathology ; Endothelin-1 - metabolism ; Hypertension, Renal - metabolism - physiopathology ; Nitric Oxide - metabolism ; Aged ; Blood Pressure ; Female ; Humans ; Male
    Divisions: Katedra za internu medicinu
    Depositing User: Boris Čičovački
    Status: Published
    Creators:
    CreatorsEmail
    Tomić, Monika
    Galešić, Krešimir
    Morović-Vergles, Jadranka
    Romić, Željko
    Mikulić, Ivanka
    Date: March 2008
    Date Deposited: 03 Oct 2008
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/388

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