CSF tau proteins in evaluation of patients with suspected dementia

Šimić, Goran and Boban, Marina and Šarac, Helena and Grbić, Kristina and Hof, Patrick R. and Hamann, C. and Ackl, Nibal and Bader, Benedikt and Danek, Adrian (2007) CSF tau proteins in evaluation of patients with suspected dementia. In: New Trends in Alzheimer and Parkinson related disorders: ADPD 2007. Medimond, Bologna, pp. 239-243. ISBN 8875874056

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Abstract

Using commercially available ELISA kits, we evaluated the diagnostic value of CSF total tau protein (t-tau), tau phosphorylated at threonine 181 and serine 199 (p-tau181 and p-tau199) in early Alzheimer's disease (AD) versus healthy controls (HC) and other primary causes of dementia, such as frontotemporal dementia (FTD), vascular dementia (VaD) and dementia with Lewy-bodies (DLB). Mean CSF t-tau and CSF p-tau181 levels were significantly elevated in AD patients compared to FTD, VaD and HC. Discrimination between AD and DLB was maximized by using p-tau181 with a sensitivity of 91% and a specificity of 94%, whereas t-tau was optimal to separate AD from VaD with a sensitivity of 91% and specificity of 95%. P-tau199 showed low specificity of 20-30% in distinguishing AD from other groups when sensitivity was set at 85% or greater. We concluded that p-tau181 and t-tau represent useful biological markers for differentiating early AD from other causes of dementia.

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