Two-year rehospitalization rates of patients with newly diagnosed or chronic schizophrenia on atypical or typical antipsychotic drugs: retrospective cohort study

Herceg, Miroslav and Jukić, Vlado and Vidović, Domagoj and Erdeljić, Viktorija and Ćelić, Ivan and Kozumplik, Oliver and Bagarić, Dario and Silobrčić Radić, Maja (2008) Two-year rehospitalization rates of patients with newly diagnosed or chronic schizophrenia on atypical or typical antipsychotic drugs: retrospective cohort study. Croatian Medical Journal, 49 (2). pp. 215-223. ISSN 0353-9504

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Abstract

AIM: To determine if atypical antipsychotic agents reduce the rehospitalization rates of patients with newly diagnosed or chronic schizophrenia in comparison with typical antipsychotic drugs. ----- METHODS: From January 1, 2003, to December 31, 2004, we retrospectively compared two-year rehospitalization rates of 135 patients with newly diagnosed schizophrenia and 398 patients with chronic schizophrenia (62% and 65% men, respectively), who were initially discharged from Vrapce Psychiatric Hospital, Zagreb, with the prescription of atypical (olanzapine, risperidone or clozapine) or typical (haloperidol or fluphenazine) antipsychotic treatment between January 1, 2002 and December 31, 2002. Time-to-readmission was determined with Kaplan-Meier formula for survival analysis. ----- RESULTS: In the two-year follow-up, 52 (39%) newly diagnosed patients and 197 (47%) patients with chronic schizophrenia were rehospitalized. No significant differences in time-to-rehospitalization were observed with respect to the type of medications in patients with newly diagnosed schizophrenia (P=0.378) or patients with chronic schizophrenia (P=0.531). ----- CONCLUSIONS: Rehospitalization rates of patients who were prescribed atypical antipsychotic drugs were similar to those of patients who were prescribed typical antipsychotic drugs for both the group with the first psychotic episode and group with chronic schizophrenia.

Abstract in Croatian

CILJ: Odrediti smanjuju li atipični antipsihotički lijekovi stopu rehospitalizacije bolesnika s novodijagnosticiranom ili kroničnom shizofrenijom više nego tipični lijekovi. ----- POSTUPCI: Od 1. siječnja 2003. do 31. prosinca 2004. retrospektivno smo uspoređivali dvogodišnje stope rehospitalizacije 135 bolesnika s novodijagnosticiranom i 398 bolesnika s kroničnom shizofrenijom (62%, odnosno 65% muškaraca) koji su otpušteni s liječenja u Psihijatrijskoj bolnici Vrapče u Zagrebu u razdoblju između 1. siječnja 2002. do 31. prosinca 2002. a bili su im prepisani atipični (olanzapin, risperidon ili klozapin) ili tipični (haloperidol ili flufenazin) antipsihotici. Vrijeme do ponovnog primanja u bolnicu određeno je Kaplan-Meierovom formulom za analizu preživljenja. ----- REZULTATI: Za vrijeme dvije godine koliko je trajalo praćenje rehospitalizirana su 52 (39%) bolesnika s novodijagnosticiranom i 197 (47%) bolesnika s kroničnom shizofrenijom. Nije bilo značajnih razlika u vremenu do rehospitalizacije s obzirom na vrstu uzimanog lijeka između bolesnika s novodijagnosticiranom (P=0,378) i bolesnika s kroničnom shizofrenijom (P=0,531). ----- ZAKLJUČAK: Stopa rehospitalizacije u bolesnika kojima su prepisani atipični antipsihotici bila je slična stopi u bolesnika kojima su prepisani tipični antipsihotici i za bolesnike s novodijagnosticiranom i za bolesnike s kroničnom shizofrenijom.

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