Krajcar, Nina and Marić, Lorna Stemberger and Šarić, Dalibor and Milić, Neven and Tešović, Goran (2019) Cefpodoxime proxetil as a therapeutic option in switching therapy for infective endocarditis in children: case reports and literature review. Journal of Chemotherapy, 31 (6). pp. 354-358. ISSN 1120-009X
![[img]](http://medlib.mef.hr/style/images/fileicons/application_pdf.png) |
PDF
- Accepted Version
Download (756kB) |
Abstract
Infective endocarditis (IE) is uncommon in children, affecting predominantly subjects with congenital heart disease (CHD) and patients with indwelling central lines. The principles of antibiotic treatment in paediatric population are similar to those in adults. Prolonged intravenous administration of bactericidal rather than bacteriostatic agents is preferred. Outpatient intravenous therapy after initial treatment in the hospital may be considered only in selected patients. Partial oral treatment has been described in cases of left-sided, uncomplicated IE caused by common pathogens in adult patients. There are no guidelines or trials in paediatric population regarding switching therapy from intravenous to oral route. We present two cases of IE in children caused by uncommon pathogenic bacteria (Abiotrophia defectiva and Haemophilus parainfluenzae) successfully treated with oral third-generation cephalosporin - cefpodoxime proxetil after initial intravenous therapy. This paper provides observations on different therapeutic approach for IE in children as well as another potential use of cefpodoxime proxetil.
| Item Type: | Article | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MeSH: | Abiotrophia ; Administration, Intravenous ; Administration, Oral ; Anti-Bacterial Agents / administration & dosage ; Ceftizoxime / administration & dosage ; Ceftizoxime / analogs & derivatives ; Child ; Child, Preschool ; Endocarditis, Bacterial / drug therapy ; Endocarditis, Bacterial / microbiology ; Female ; Gram-Positive Bacterial Infections / complications ; Gram-Positive Bacterial Infections / drug therapy ; Haemophilus Infections / complications ; Haemophilus Infections / drug therapy ; Humans ; Male | ||||||||||||
| Departments: | Katedra za infektologiju | ||||||||||||
| Depositing User: | Kristina Berketa | ||||||||||||
| Status: | Published | ||||||||||||
| Creators: |
|
||||||||||||
| Date: | 31 October 2019 | ||||||||||||
| Date Deposited: | 23 Sep 2020 09:29 | ||||||||||||
| Last Modified: | 23 Sep 2020 09:29 | ||||||||||||
| Subjects: | / | ||||||||||||
| Related URLs: | |||||||||||||
| URI: | http://medlib.mef.hr/id/eprint/3675 |
Actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
