Povezanost kliničkih, laboratorijskih i termografskih nalaza u bolesnika s ulceroznim kolitisom [Association between clinical, laboratory and thermographic findings in patients with ulcerative colitis]

Božin, Tonći (2020) Povezanost kliničkih, laboratorijskih i termografskih nalaza u bolesnika s ulceroznim kolitisom [Association between clinical, laboratory and thermographic findings in patients with ulcerative colitis]. PhD thesis, Sveučilište u Zagrebu.

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Abstract

INTRODUCTION: The aim of this paper was to describe the diagnostic potential of thermography in surveillance and as a noninvasive biomarker of disease activity in patients with extensive ulcerative colitis. MATERIAL AND METHODS: 30 patients with active extensive colitis and 30 healthy subjects where enrolled in the study. Patients where prospectively followed and treated for 6 months. All of the participants where subject to infrared thermography at enrollment but UC patients were screened once more after 6 months. Thermographic criteria (Tsred ROI 1 – 4) where compared among the two groups of participants but also compared to standard clinical, laboratory and endoscopic markers of disease activity. RESULTS: higher temperatures were observed among patients with active ulcerative colitis compared to healthy subjects as well as in patients with active disease compared to those in remission after 6 months. Statistically significant correlation was observed between average abdominal temperatures and clinical (Mayo score), laboratory (FC, CRP) and endoscopic findings (Mayo ESS) in patients with ulcerative colitis. CONCLUSION: This paper depicts static abdominal thermography as a potential noninvasive tool for screening and surveillance of patients with extensive ulcerative colitis.

Abstract in Croatian

UVOD: Cilj ovog istraživanja bio je prikazati dijagnostički potencijal infracrvene termografije kao neinvazivnog biomarkera aktivnosti ekstenzivnog ulceroznog kolitisa i njen potencijal u praćenju odgovora na terapiju. MATERIJALI I METODE: U istraživanje je uključeno 30 bolesnika s aktivnim ekstenzivnim kolitisom i 30 zdravih ispitanika. Bolesnici su praćeni tijekom šest mjeseci liječenja. Svi ispitanici su podvrgnuti termografskom snimanju kod uključivanja u istraživanje, a bolesnicima je nakon perioda praćenja ponovljeno termografsko snimanje. Termografski kriteriji (Tsred ROI 1 – 4) su komparirani među promatranim skupinama te komparirani s kliničkim, laboratorijskim i endoskopskim parametrima aktivnosti ulceroznog kolitisa. REZULTATI: Dokumentirane su značajno više temperature u termogramu bolesnika s aktivnim ulceroznim kolitisom u odnosu na temperature u termogramu zdravih ispitanika kao i u bolesnika koji nisu postigli remisiju u odnosu na bolesnike u remisiji. Zabilježena je povezanost srednjaka temperatura i kliničkih (Mayo), laboratorijskih (FC, CRP) i endoskopskog nalaza (Mayo ESS) u skupini bolesnika s ulceroznim kolitisom. ZAKLJUČAK: Statična termografija abdomena pokazuje potencijal u dijagnostici i praćenju bolesnika s ekstenzivnim ulceroznim kolitisom.

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