The effects of L-carnitine supplementation on glycemic control: a systematic review and meta-analysis of randomized controlled trials

Fathizadeh, Hadis and Milajerdi, Alireza and Reiner, Željko and Kolahdooz, Fariba and Asemi, Zatollah (2019) The effects of L-carnitine supplementation on glycemic control: a systematic review and meta-analysis of randomized controlled trials. EXCLI journal, 18. pp. 631-643. ISSN 1611-2156

[img] PDF - Published Version
Download (372kB)

Abstract

The findings of trials investigating the effect of L-carnitine administration on glycemic control are controversial. This meta-analysis of randomized controlled trials (RCTs) was performed to explore the effects of L-carnitine intake on glycemic control. Two authors independently searched electronic databases including MEDLINE, EMBASE, Cochrane Library, Web of Science, PubMed and Google scholar from 1990 until February 2019, in order to find relevant RCTs. 37 studies with 44 effect sizes met the inclusion criteria and were eligible for the meta-analysis. L-carnitine supplementation resulted in a significant reduction in fasting plasma glucose (FPG) (WMD: -4.57; 95 % CI: -6.88, -2.25), insulin (WMD: -1.21; 95 % CI: -1.85, -0.57), homeostatic model assessment for insulin resistance (HOMA-IR) (WMD: -0.67; 95 % CI: -0.90, -0.44) and HbA1C concentrations (WMD: -0.30; 95 % CI: -0.47, -0.13). L-Carnitine supplementation significantly reduced FPG, insulin, HOMA-IR, and HbA1c levels.

Item Type: Article
Additional Information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Departments: Katedra za internu medicinu
Depositing User: Kristina Berketa
Status: Published
Creators:
CreatorsEmail
Fathizadeh, HadisUNSPECIFIED
Milajerdi, AlirezaUNSPECIFIED
Reiner, ŽeljkoUNSPECIFIED
Kolahdooz, FaribaUNSPECIFIED
Asemi, ZatollahUNSPECIFIED
Date: 19 August 2019
Date Deposited: 27 Apr 2020 14:02
Last Modified: 27 Apr 2020 14:02
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/3592

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year