Toxic liver injury after high-dose methylprednisolone in people with multiple sclerosis

Adamec, Ivan and Pavlović, Ivan and Pavičić, Tin and Ruška, Berislav and Habek, Mario (2018) Toxic liver injury after high-dose methylprednisolone in people with multiple sclerosis. Multiple Sclerosis and Related Disorders, 25. pp. 43-45. ISSN 2211-0348

PDF - Accepted Version
Download (1MB)

Official URL: http://doi.org/10.1016/j.msard.2018.07.021

Abstract

The standard therapy of multiple sclerosis (MS) relapse is high-dose pulse corticosteroid therapy. Although commonly applied and usually well tolerated it may as well carry certain risks for people with MS, the more severe of them being hepatotoxicity. This report describes three cases of acute liver injury following pulse corticosteroid therapy with reference to other possible causative factors. Caution should be exercised when applying high-dose methylprednisolone given the potential liver related adverse events it may cause.

Item Type:

Article

MeSH:

Adult ; Anti-Inflammatory Agents / administration & dosage ; Chemical and Drug Induced Liver Injury / etiology ; Female ; Humans ; Methylprednisolone / adverse effects ; Middle Aged ; Multiple Sclerosis / drug therapy

Departments:

Katedra za neurologiju

Depositing User:

Kristina Berketa

Status:

Published

Creators: