Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?

Ilić, Katarina and Auer, Benedikt and Mlinac-Jerković, Kristina and Herrera-Molina, Rodrigo (2019) Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity? Frontiers in Cell and Developmental Biology, 7. ISSN 2296-634X

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Official URL: http://doi.org/10.3389/fcell.2019.00027

Abstract

Thy-1 is a small membrane glycoprotein and member of the immunoglobulin superfamily of cell adhesion molecules. It is abundantly expressed in many cell types including neurons and is anchored to the outer membrane leaflet via a glycosyl phosphatidylinositol tail. Thy-1 displays a number of interesting properties such as fast lateral diffusion, which allows it to get in and out of membrane nanodomains with different lipid composition. Thy-1 displays a broad expression in different cell types and plays confirmed roles in cell development, adhesion and differentiation. Here, we explored the functions of Thy-1 in neuronal signaling, initiated by extracellular binding of aVb3 integrin, may strongly dependent on the lipid content of the cell membrane. Also, we assort literature suggesting the association of Thy-1 with specific components of lipid rafts such as sialic acid containing glycosphingolipids, called gangliosides. Furthermore, we argue that Thy-1 positioning in nanodomains may be influenced by gangliosides. We propose that the traditional conception of Thy-1 localization in rafts should be reconsidered and evaluated in detail based on the potential diversity of neuronal nanodomains.

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Article

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Copyright © 2019 Ilic, Auer, Mlinac-Jerkovic and Herrera-Molina. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Departments:

Hrvatski institut za istraživanje mozga
Katedra za medicinsku kemiju, biokemiju i kliničku kemiju

Depositing User:

Kristina Berketa

Status:

Published

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