Latent Toxoplasma gondii infection is associated with decreased serum triglyceride to high-density lipoprotein cholesterol ratio in male patients with schizophrenia

Šagud, Marina and Vlatković, Suzana and Švob Štrac, Dubravka and Sviben, Mario and Živković, Maja and Vilibić, Maja and Vuksan-Ćusa, Bjanka and Mihaljević-Peleš, Alma and Pivac, Nela (2018) Latent Toxoplasma gondii infection is associated with decreased serum triglyceride to high-density lipoprotein cholesterol ratio in male patients with schizophrenia. Comprehensive Psychiatry, 82. pp. 115-120. ISSN 0010-440X

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BACKGROUND: Previous studies suggested a complex association between Toxoplasma gondii (TG) infection and host lipid metabolism. Both TG infection and metabolic disturbances are very common in patients with schizophrenia, but this relationship is not clear. ----- METHODS: In this cross-sectional study, we evaluated the association between TG seropositivity, serum lipid levels, body mass index (BMI) and metabolic syndrome (MetS) in 210 male inpatients with schizophrenia. ----- RESULTS: In our sample of schizophrenia patients, with the mean age of 43.90 ± 12.70 years, the rate of TG seropositivity was 52.38% and the prevalence of MetS was 17%. Patients with the TG antibodies had lower serum triglyceride levels and body weight compared to TG seronegative patients, despite having more frequently received antipsychotics (clozapine, olanzapine risperidone and quetiapine), which are well known to induce weight gain and metabolic abnormalities. However, the only significant change in metabolic parameters, observed in TG seropositive patients with schizophrenia, was decreased serum triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio. No associations were observed between TG seropositivity and serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and glucose levels, waist circumference, BMI and the rate of MetS. ----- CONCLUSION: This is the first report of the association between TG infection and decreased serum triglyceride to HDL-C ratio in a sample of carefully selected men with chronic schizophrenia.

Item Type: Article
MeSH: Adult ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Body Mass Index ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Humans ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/chemically induced ; Metabolic Syndrome/diagnosis ; Middle Aged ; Schizophrenia/blood ; Schizophrenia/diagnosis ; Schizophrenia/drug therapy ; Toxoplasmosis/blood ; Toxoplasmosis/diagnosis ; Triglycerides/blood ; Waist Circumference/physiology ; Weight Gain/drug effects ; Weight Gain/physiology
Departments: Katedra za psihijatriju i psihološku medicinu
Depositing User: Kristina Berketa
Status: Published
Vlatković, SuzanaUNSPECIFIED
Švob Štrac, DubravkaUNSPECIFIED
Vuksan-Ćusa, BjankaUNSPECIFIED
Mihaljević-Peleš, AlmaUNSPECIFIED
Date: April 2018
Date Deposited: 17 Oct 2019 10:59
Last Modified: 27 Aug 2020 08:24
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