Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia

Višković, Klaudija and Židovec Lepej, Snježana and Gorenec, Ana and Grgić, Ivana and Lukas, Davorka and Zekan, Šime and Dragobratović, Anja and Trupković, Maja and Begovac, Josip (2018) Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia. Scientific Reports, 8 (1). p. 6113. ISSN 2045-2322

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Patients successfully treated for HIV infection still have an increased risk for cardiovascular morbidity and mortality, which might be related not only to traditional risks, but also to inflammation and dyslipidemia. We examined the relationship of serum lipid levels with plasma biomarkers of inflammation using a composite inflammatory burden score (IBS) based on individual (>75th percentile) measurements from the following seven markers: CD40L, tPA, MCP-1, IL-8, IL-6, hCRP and P-selectin. IBS was categorized as 0 (none of the biomarkers >75th percentile), 1, 2 and 3 or more scores. Correlations between the IBS and lipid parameters were examined by ordered logistic regression proportional odds models to estimate the odds of more elevated biomarkers. 181 male patients with undetectable HIV-viremia were included into the study. In the multivariate model, a one-unit increase (mmol/L) of total cholesterol and triglycerides was associated with a 1.41-fold (95% CI, 1.13-1.76) and 1.37-fold (95% CI, 1.18-1.60) increased odds of having a greater IBS, respectively. Those with an IBS score ≥1 compared to none had 2.14 (95% CI, 1.43-3.20) higher odds of having a one-unit increased total cholesterol/HDL-cholesterol ratio. In successfully treated HIV-infected persons dyslipidemia was associated with inflammation.

Item Type: Article
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit © The Author(s) 2018
Departments: Katedra za infektologiju
Depositing User: Kristina Berketa
Status: Published
Višković, KlaudijaUNSPECIFIED
Židovec Lepej, SnježanaUNSPECIFIED
Dragobratović, AnjaUNSPECIFIED
Trupković, MajaUNSPECIFIED
Date: 17 April 2018
Date Deposited: 02 Oct 2019 07:45
Last Modified: 02 Oct 2019 07:45
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