Ariel, Amnon and Altraja, Alan and Belevskiy, Andrey and Boros, Piotr and Danila, Edvardas and Flezar, Matjaz and Koblizek, Vladimir and Fridlender, Zvi Gregorio and Kostov, Kosta and Krams, Alvils and Milenkovic, Branislava and Somfay, Attila and Tkacova, Ruzena and Tudorić, Neven and Ulmeanu, Ruxandra and Valipour, Arschang (2017) Inhaled therapies in patients with moderate COPD in clinical practice: current thinking. International Journal of Chronic Obstructive Pulmonary Disease, 13. pp. 45-56. ISSN 1178-2005
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Abstract
COPD is a complex, heterogeneous condition. Even in the early clinical stages, COPD carries a significant burden, with breathlessness frequently leading to a reduction in exercise capacity and changes that correlate with long-term patient outcomes and mortality. Implementation of an effective management strategy is required to reduce symptoms, preserve lung function, quality of life, and exercise capacity, and prevent exacerbations. However, current clinical practice frequently differs from published guidelines on the management of COPD. This review focuses on the current scientific evidence and expert opinion on the management of moderate COPD: the symptoms arising from moderate airflow obstruction and the burden these symptoms impose, how physical activity can improve disease outcomes, the benefits of dual bronchodilation in COPD, and the limited evidence for the benefits of inhaled corticosteroids in this disease. We emphasize the importance of maximizing bronchodilation in COPD with inhaled dual-bronchodilator treatment, enhancing patient-related outcomes, and enabling the withdrawal of inhaled corticosteroids in COPD in well-defined patient groups.
| Item Type: | Article | ||||||||||||||||||||||||||||||||||
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| Additional Information: | © 2018 Ariel et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). | ||||||||||||||||||||||||||||||||||
| MeSH: | Administration, Inhalation ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/adverse effects ; Adrenergic beta-2 Receptor Agonists/administration & dosage ; Adrenergic beta-2 Receptor Agonists/adverse effects ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/adverse effects ; Disease Progression ; Exercise Tolerance/drug effects ; Health Status ; Humans ; Lung/drug effects ; Lung/physiopathology ; Muscarinic Antagonists/administration & dosage ; Muscarinic Antagonists/adverse effects ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Quality of Life ; Recovery of Function ; Risk Factors ; Severity of Illness Index ; Treatment Outcome | ||||||||||||||||||||||||||||||||||
| Departments: | Katedra za internu medicinu | ||||||||||||||||||||||||||||||||||
| Depositing User: | Kristina Berketa | ||||||||||||||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||||||||||||||
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| Date: | 21 December 2017 | ||||||||||||||||||||||||||||||||||
| Date Deposited: | 20 Sep 2019 07:38 | ||||||||||||||||||||||||||||||||||
| Last Modified: | 17 Aug 2020 07:43 | ||||||||||||||||||||||||||||||||||
| Subjects: | / | ||||||||||||||||||||||||||||||||||
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| URI: | http://medlib.mef.hr/id/eprint/3365 |
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