Multiple myeloma treatment in real-world clinical practice: results of a prospective, multinational, noninterventional study

Mohty, Mohamad and Terpos, Evangelos and Mateos, Maria-Victoria and Cavo, Michele and Lejniece, Sandra and Beksac, Meral and Bekadja, Mohamed Amine and Legiec, Wojciech and Dimopoulos, Meletios and Stankovic, Svetlana and Durán, Maria Soledad and De Stefano, Valerio and Corso, Alessandro and Kochkareva, Yulia and Laane, Edward and Berthou, Christian and Salwender, Hans and Masliak, Zvenyslava and Pečeliūnas, Valdas and Willenbacher, Wolfgang and Silva, João and Louw, Vernon and Nemet, Damir and Borbényi, Zita and Abadi, Uri and Pedersen, Robert Schou and Černelč, Peter and Potamianou, Anna and Couturier, Catherine and Feys, Caroline and Thoret-Bauchet, Florence and Boccadoro, Mario and Bekadja, Mohamed and Hamladji, Rose-Marie and Ali, Hocine Ait and Hamdi, Selma and Touhami, Hadj and Mansour, Nourredine Sidi and Willenbacher, Wolfgang and Linkesch, Werner and Nemet, Damir and Pedersen, Robert Shou and Abildgaard, Niels and Laane, Edward and Hein, Marju and Mohty, Mohamad and Eveillard, Jean Richard and Yamani, Abderrazak el and Moreau, Philippe and Sanhes, Laurence and Lepeu, Gérard and Laribi, Kamel and Jourdan, Eric and Fitoussi, Olivier and Allangba, Olivier and Fleury, Joël and Escoffre, Martine and Benramdane, Riad and Cartron, Guillaume and Dine, Gérard and Legouffe, Eric and Harich, Hanns-Detlev and Illmer, Thomas and Dörfel, Steffen and Hannig, Carla Verena and Koenigsmann, Michael and Prange-Krex, Gabriele and Salwender, Hans and Tamm, Ingo and Zeller, Wolfgang and Maasberg, Michael and Schlag, Rudolf and Klausmann, Martine and Uhlig, Jens and Alkemper, Burkhard and Schütz, Stefan and Tessen, Hans-Werner and Mohr, Benno and Schmidt, Peter and Heinrich, Bernhard and Hebart, Holger and Seipelt, Gernot and Zoeller, Thomas and Heits, Frank and Müller-Naendrup, Clemens and Hansen, Richard and Repp, Roland and Von Weikersthal, Ludwig Fischer and Schmits, Rudolf and Heßling, Jörg and Krammer-Steiner, B. and Janzen, Viktor and Schauer, Michael and Grüner, Marcus W. and Kisro, Jens and Denzlinger, Claudio and Freier, Werner and Junghanss, Christian and Görner, Martin and Laichinger, Katharina and Ostermann, Helmut and Dürk, Heinz and Hess, Georg and Reich, Gernot and Terpos, Evangelos and Dimopoulos, Meletios and Matsouka, Panagiota and Pouli, Anastasia and Anagnostopoulos, Achilles and Masszi, Tamas and Borbényi, Zita and Ivanyi, Janos and Szomor, Arpad and Abadi, Uri and Nagler, Arnon and Magen, Hila and Avivi, Irit and Quitt, Miriam and Palumbo, Antonio and Boccadoro, Mario and De Stefano, Valerio and Za, Tommaso and Vallisa, Daniele and Foa, Roberto and Corso, Alessandro and Bosi, Alberto and Vacca, Angelo and Lanza, Francesco and Palazzo, Giulia and Avvisati, Giuseppe and Cavo, Michele and Ferrara, Felicetto and Consoli, Ugo and Cantonetti, Maria and Angelucci, Emanuele and Califano, Catello and Di Raimondo, Francesco and Guarini, Attilio and Musso, Maurizio and Pizzuti, Michele and Giuliani, Nicola and Ardizzoia, Antonio and Di Renzo, Nicola and Gaidano, Gianluca and Gozzetti, Alessandro and Pitini, Vincenzo and Farina, Gabriella and Centurioni, Riccardo and De Fabritiis, Paolo and Iuliano, Francesco and La Nasa, Giorgio and La Verde, Giacinto and Pane, Fabrizio and Recine, Umberto and La Targia, Maria and Mineo, Giuseppe and Cangialosi, Clotilde and Fagnani, Daniele and Federici, Augusto and Romano, Atelda and Specchia, Giorgina and Storti, Sergio and Bongarzoni, Velia and Bacigalupo, Andrea and Gobbi, Marco and Latte, Giancarlo and Mannina, Donato and Capalbo, Silvana and Lejniece, Sandra and Pečeliūnas, Valdas and Jurgutis, Mindaugas and Stankovic, Svetlana and Legiec, Wojciech and Woszczyk, Dariusz and Hołojda, Jadwiga and Gornik, Slawomir and Pluta, Andrzej and Morawiec-Szymonik, Elzbieta and Kyrcz-Krzemien, Slawomira and Homenda, Wojciech and Grosicki, Sebastian and Sulek, Kazimierz and Lange, Andrzej and Kloczko, Janusz and Starzak-Gwozdz, Jolanta and Hellmann, Andrzej and Komarnicki, Mieczyslaw and Kuliczkowski, Kazimierz and Viveiros, Carolina and Gonçalves, Cristina and Esefyeva, Natalia and Kochkareva, Julia and Kaplanov, Kamil and Volodicheva, Elena and Laricheva, Elena and Dergacheva, Valentina and Chukavina, Marina and Volchenko, Natalia and Nazarova, Irina and Anchukova, Ludmila and Ovanesova, Elena and Gritsenko, Taras and Salogub, Galina and Magomedova, Ludmila and Kuznetsova, Irina and Osyunikhina, Svetlana and Serdyuk, Olga and Karyagina, Elena and Ivanova, Valentina and Černelč, Slovenia Peter and Louw, Vernon and Coetzee, Corlia and Gunther, Karen and Moodley, Dhayanithi and Duran, Soledad and Gutiérrez, Asunción Echeveste and De Oteyza, Jaime Perez and Capote, Francisco Javier and Casanova, Maria and Sanchez, Jesus Martin and Rios-Herranz, Eduardo and Ibañez-Garcia, Jeronima and Herranz, Maria Jose and Hernandez, Belen and Sanchez, Sara Sanchez and Escalante, Fernando and Carnicero, Fernando and Lleonart, Joan Bargay and Gironella, Mercedes and Martínez, Rafael and De La Guia, Ana Lopez and Palomera, Luis and Iglesias, Rebeca and Ramos, Fernando Solano and De La Serna, Javier and Sanchez, Pedro Garcia and Vidal, Juan Besalduch and Mateos, Maria-Victoria and Morfa, Miguel Diaz and Beksac, Turkey – Meral and Vural, Filiz and Aydin, Yildiz and Unal, Ali and Goker, Hakan and Bilgir, Oktay and Guvenc, Birol and Turgut, Mehmet and Ozet, Gulsum Gulistan and Ali, Ridvan and Masliak, Zvenyslava and Kyselyova, Maryna and Glushko, Nataliia and Vybyrana, Renata and Skrypnyk, Igor and Tretyak, Natalya and Kharchevska, Tetiana and Dyagil, Iryna and Popovs'ka, Tetiana and Shimanskiy, Vadim and Lysa, Tamila and Oliynyk, Hanna and Vilchevskaya, Kateryna and Kryachok, Iryna and Popovych, Yuriy and Romanyuk, Natalia and Yushchenko, Natalia and Kaplan, Polina and Rekhtman, Grygoriy and Pylypenko, Halyna and Kozlov, Viktor and Mohty, Mohamad and Terpos, Evangelos and Mateos, Maria-Victoria and Palumbo, Antonio and Drach, Johannes and Boccadoro, Mario and Harousseau, Jean-Luc and Einsele, Hermann and Goldschmidt, Hartmut and Facon, Thierry and Michalet, Mauricette and Savchenko, Valery G. and De la Rubia, Javier and Cook, Gordon and Mellqvist, Ulf-Henrik and Ludwig, Heinz (2018) Multiple myeloma treatment in real-world clinical practice: results of a prospective, multinational, noninterventional study. Clinical lymphoma, myeloma & leukemia, 18 (10). e401-e419. ISSN 2152-2650

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Abstract

BACKGROUND: The present prospective, multinational, noninterventional study aimed to document and describe real-world treatment regimens and disease progression in multiple myeloma (MM) patients. ----- PATIENTS AND METHODS: Adult patients initiating any new MM therapy from October 2010 to October 2012 were eligible. A multistage patient/site recruitment model was applied to minimize the selection bias; enrollment was stratified by country, region, and practice type. The patient medical and disease features, treatment history, and remission status were recorded at baseline, and prospective data on treatment, efficacy, and safety were collected electronically every 3 months. ----- RESULTS: A total of 2358 patients were enrolled. Of these patients, 775 and 1583 did and did not undergo stem cell transplantation (SCT) at any time during treatment, respectively. Of the patients in the SCT and non-SCT groups, 49%, 21%, 14%, and 15% and 57%, 20%, 12% and 10% were enrolled at treatment line 1, 2, 3, and ≥ 4, respectively. In the SCT and non-SCT groups, 45% and 54% of the patients had received bortezomib-based therapy without thalidomide/lenalidomide, 12% and 18% had received thalidomide/lenalidomide-based therapy without bortezomib, and 30% and 4% had received bortezomib plus thalidomide/lenalidomide-based therapy as frontline treatment, respectively. The corresponding proportions of SCT and non-SCT patients in lines 2, 3, and ≥ 4 were 45% and 37%, 30% and 37%, and 12% and 3%, 33% and 27%, 35% and 32%, and 8% and 2%, and 27% and 27%, 27% and 23%, and 6% and 4%, respectively. In the SCT and non-SCT patients, the overall response rate was 86% to 97% and 64% to 85% in line 1, 74% to 78% and 59% to 68% in line 2, 55% to 83% and 48% to 60% in line 3, and 49% to 65% and 36% and 45% in line 4, respectively, for regimens that included bortezomib and/or thalidomide/lenalidomide. ----- CONCLUSION: The results of our prospective study have revealed great diversity in the treatment regimens used to manage MM in real-life practice. This diversity was linked to factors such as novel agent accessibility and evolving treatment recommendations. Our results provide insight into associated clinical benefits.

Item Type: Article
Additional Information: © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Departments: Katedra za internu medicinu
Depositing User: Kristina Berketa
Status: Published
Creators:
CreatorsEmail
Mohty, MohamadUNSPECIFIED
Terpos, EvangelosUNSPECIFIED
Mateos, Maria-VictoriaUNSPECIFIED
Cavo, MicheleUNSPECIFIED
Lejniece, SandraUNSPECIFIED
Beksac, MeralUNSPECIFIED
Bekadja, Mohamed AmineUNSPECIFIED
Legiec, WojciechUNSPECIFIED
Dimopoulos, MeletiosUNSPECIFIED
Stankovic, SvetlanaUNSPECIFIED
Durán, Maria SoledadUNSPECIFIED
De Stefano, ValerioUNSPECIFIED
Corso, AlessandroUNSPECIFIED
Kochkareva, YuliaUNSPECIFIED
Laane, EdwardUNSPECIFIED
Berthou, ChristianUNSPECIFIED
Salwender, HansUNSPECIFIED
Masliak, ZvenyslavaUNSPECIFIED
Pečeliūnas, ValdasUNSPECIFIED
Willenbacher, WolfgangUNSPECIFIED
Silva, JoãoUNSPECIFIED
Louw, VernonUNSPECIFIED
Nemet, DamirUNSPECIFIED
Borbényi, ZitaUNSPECIFIED
Abadi, UriUNSPECIFIED
Pedersen, Robert SchouUNSPECIFIED
Černelč, PeterUNSPECIFIED
Potamianou, AnnaUNSPECIFIED
Couturier, CatherineUNSPECIFIED
Feys, CarolineUNSPECIFIED
Thoret-Bauchet, FlorenceUNSPECIFIED
Boccadoro, MarioUNSPECIFIED
Bekadja, MohamedUNSPECIFIED
Hamladji, Rose-MarieUNSPECIFIED
Ali, Hocine AitUNSPECIFIED
Hamdi, SelmaUNSPECIFIED
Touhami, HadjUNSPECIFIED
Mansour, Nourredine SidiUNSPECIFIED
Willenbacher, WolfgangUNSPECIFIED
Linkesch, WernerUNSPECIFIED
Nemet, DamirUNSPECIFIED
Pedersen, Robert ShouUNSPECIFIED
Abildgaard, NielsUNSPECIFIED
Laane, EdwardUNSPECIFIED
Hein, MarjuUNSPECIFIED
Mohty, MohamadUNSPECIFIED
Eveillard, Jean RichardUNSPECIFIED
Yamani, Abderrazak elUNSPECIFIED
Moreau, PhilippeUNSPECIFIED
Sanhes, LaurenceUNSPECIFIED
Lepeu, GérardUNSPECIFIED
Laribi, KamelUNSPECIFIED
Jourdan, EricUNSPECIFIED
Fitoussi, OlivierUNSPECIFIED
Allangba, OlivierUNSPECIFIED
Fleury, JoëlUNSPECIFIED
Escoffre, MartineUNSPECIFIED
Benramdane, RiadUNSPECIFIED
Cartron, GuillaumeUNSPECIFIED
Dine, GérardUNSPECIFIED
Legouffe, EricUNSPECIFIED
Harich, Hanns-DetlevUNSPECIFIED
Illmer, ThomasUNSPECIFIED
Dörfel, SteffenUNSPECIFIED
Hannig, Carla VerenaUNSPECIFIED
Koenigsmann, MichaelUNSPECIFIED
Prange-Krex, GabrieleUNSPECIFIED
Salwender, HansUNSPECIFIED
Tamm, IngoUNSPECIFIED
Zeller, WolfgangUNSPECIFIED
Maasberg, MichaelUNSPECIFIED
Schlag, RudolfUNSPECIFIED
Klausmann, MartineUNSPECIFIED
Uhlig, JensUNSPECIFIED
Alkemper, BurkhardUNSPECIFIED
Schütz, StefanUNSPECIFIED
Tessen, Hans-WernerUNSPECIFIED
Mohr, BennoUNSPECIFIED
Schmidt, PeterUNSPECIFIED
Heinrich, BernhardUNSPECIFIED
Hebart, HolgerUNSPECIFIED
Seipelt, GernotUNSPECIFIED
Zoeller, ThomasUNSPECIFIED
Heits, FrankUNSPECIFIED
Müller-Naendrup, ClemensUNSPECIFIED
Hansen, RichardUNSPECIFIED
Repp, RolandUNSPECIFIED
Von Weikersthal, Ludwig FischerUNSPECIFIED
Schmits, RudolfUNSPECIFIED
Heßling, JörgUNSPECIFIED
Krammer-Steiner, B.UNSPECIFIED
Janzen, ViktorUNSPECIFIED
Schauer, MichaelUNSPECIFIED
Grüner, Marcus W.UNSPECIFIED
Kisro, JensUNSPECIFIED
Denzlinger, ClaudioUNSPECIFIED
Freier, WernerUNSPECIFIED
Junghanss, ChristianUNSPECIFIED
Görner, MartinUNSPECIFIED
Laichinger, KatharinaUNSPECIFIED
Ostermann, HelmutUNSPECIFIED
Dürk, HeinzUNSPECIFIED
Hess, GeorgUNSPECIFIED
Reich, GernotUNSPECIFIED
Terpos, EvangelosUNSPECIFIED
Dimopoulos, MeletiosUNSPECIFIED
Matsouka, PanagiotaUNSPECIFIED
Pouli, AnastasiaUNSPECIFIED
Anagnostopoulos, AchillesUNSPECIFIED
Masszi, TamasUNSPECIFIED
Borbényi, ZitaUNSPECIFIED
Ivanyi, JanosUNSPECIFIED
Szomor, ArpadUNSPECIFIED
Abadi, UriUNSPECIFIED
Nagler, ArnonUNSPECIFIED
Magen, HilaUNSPECIFIED
Avivi, IritUNSPECIFIED
Quitt, MiriamUNSPECIFIED
Palumbo, AntonioUNSPECIFIED
Boccadoro, MarioUNSPECIFIED
De Stefano, ValerioUNSPECIFIED
Za, TommasoUNSPECIFIED
Vallisa, DanieleUNSPECIFIED
Foa, RobertoUNSPECIFIED
Corso, AlessandroUNSPECIFIED
Bosi, AlbertoUNSPECIFIED
Vacca, AngeloUNSPECIFIED
Lanza, FrancescoUNSPECIFIED
Palazzo, GiuliaUNSPECIFIED
Avvisati, GiuseppeUNSPECIFIED
Cavo, MicheleUNSPECIFIED
Ferrara, FelicettoUNSPECIFIED
Consoli, UgoUNSPECIFIED
Cantonetti, MariaUNSPECIFIED
Angelucci, EmanueleUNSPECIFIED
Califano, CatelloUNSPECIFIED
Di Raimondo, FrancescoUNSPECIFIED
Guarini, AttilioUNSPECIFIED
Musso, MaurizioUNSPECIFIED
Pizzuti, MicheleUNSPECIFIED
Giuliani, NicolaUNSPECIFIED
Ardizzoia, AntonioUNSPECIFIED
Di Renzo, NicolaUNSPECIFIED
Gaidano, GianlucaUNSPECIFIED
Gozzetti, AlessandroUNSPECIFIED
Pitini, VincenzoUNSPECIFIED
Farina, GabriellaUNSPECIFIED
Centurioni, RiccardoUNSPECIFIED
De Fabritiis, PaoloUNSPECIFIED
Iuliano, FrancescoUNSPECIFIED
La Nasa, GiorgioUNSPECIFIED
La Verde, GiacintoUNSPECIFIED
Pane, FabrizioUNSPECIFIED
Recine, UmbertoUNSPECIFIED
La Targia, MariaUNSPECIFIED
Mineo, GiuseppeUNSPECIFIED
Cangialosi, ClotildeUNSPECIFIED
Fagnani, DanieleUNSPECIFIED
Federici, AugustoUNSPECIFIED
Romano, AteldaUNSPECIFIED
Specchia, GiorginaUNSPECIFIED
Storti, SergioUNSPECIFIED
Bongarzoni, VeliaUNSPECIFIED
Bacigalupo, AndreaUNSPECIFIED
Gobbi, MarcoUNSPECIFIED
Latte, GiancarloUNSPECIFIED
Mannina, DonatoUNSPECIFIED
Capalbo, SilvanaUNSPECIFIED
Lejniece, SandraUNSPECIFIED
Pečeliūnas, ValdasUNSPECIFIED
Jurgutis, MindaugasUNSPECIFIED
Stankovic, SvetlanaUNSPECIFIED
Legiec, WojciechUNSPECIFIED
Woszczyk, DariuszUNSPECIFIED
Hołojda, JadwigaUNSPECIFIED
Gornik, SlawomirUNSPECIFIED
Pluta, AndrzejUNSPECIFIED
Morawiec-Szymonik, ElzbietaUNSPECIFIED
Kyrcz-Krzemien, SlawomiraUNSPECIFIED
Homenda, WojciechUNSPECIFIED
Grosicki, SebastianUNSPECIFIED
Sulek, KazimierzUNSPECIFIED
Lange, AndrzejUNSPECIFIED
Kloczko, JanuszUNSPECIFIED
Starzak-Gwozdz, JolantaUNSPECIFIED
Hellmann, AndrzejUNSPECIFIED
Komarnicki, MieczyslawUNSPECIFIED
Kuliczkowski, KazimierzUNSPECIFIED
Viveiros, CarolinaUNSPECIFIED
Gonçalves, CristinaUNSPECIFIED
Esefyeva, NataliaUNSPECIFIED
Kochkareva, JuliaUNSPECIFIED
Kaplanov, KamilUNSPECIFIED
Volodicheva, ElenaUNSPECIFIED
Laricheva, ElenaUNSPECIFIED
Dergacheva, ValentinaUNSPECIFIED
Chukavina, MarinaUNSPECIFIED
Volchenko, NataliaUNSPECIFIED
Nazarova, IrinaUNSPECIFIED
Anchukova, LudmilaUNSPECIFIED
Ovanesova, ElenaUNSPECIFIED
Gritsenko, TarasUNSPECIFIED
Salogub, GalinaUNSPECIFIED
Magomedova, LudmilaUNSPECIFIED
Kuznetsova, IrinaUNSPECIFIED
Osyunikhina, SvetlanaUNSPECIFIED
Serdyuk, OlgaUNSPECIFIED
Karyagina, ElenaUNSPECIFIED
Ivanova, ValentinaUNSPECIFIED
Černelč, Slovenia PeterUNSPECIFIED
Louw, VernonUNSPECIFIED
Coetzee, CorliaUNSPECIFIED
Gunther, KarenUNSPECIFIED
Moodley, DhayanithiUNSPECIFIED
Duran, SoledadUNSPECIFIED
Gutiérrez, Asunción EchevesteUNSPECIFIED
De Oteyza, Jaime PerezUNSPECIFIED
Capote, Francisco JavierUNSPECIFIED
Casanova, MariaUNSPECIFIED
Sanchez, Jesus MartinUNSPECIFIED
Rios-Herranz, EduardoUNSPECIFIED
Ibañez-Garcia, JeronimaUNSPECIFIED
Herranz, Maria JoseUNSPECIFIED
Hernandez, BelenUNSPECIFIED
Sanchez, Sara SanchezUNSPECIFIED
Escalante, FernandoUNSPECIFIED
Carnicero, FernandoUNSPECIFIED
Lleonart, Joan BargayUNSPECIFIED
Gironella, MercedesUNSPECIFIED
Martínez, RafaelUNSPECIFIED
De La Guia, Ana LopezUNSPECIFIED
Palomera, LuisUNSPECIFIED
Iglesias, RebecaUNSPECIFIED
Ramos, Fernando SolanoUNSPECIFIED
De La Serna, JavierUNSPECIFIED
Sanchez, Pedro GarciaUNSPECIFIED
Vidal, Juan BesalduchUNSPECIFIED
Mateos, Maria-VictoriaUNSPECIFIED
Morfa, Miguel DiazUNSPECIFIED
Beksac, Turkey – MeralUNSPECIFIED
Vural, FilizUNSPECIFIED
Aydin, YildizUNSPECIFIED
Unal, AliUNSPECIFIED
Goker, HakanUNSPECIFIED
Bilgir, OktayUNSPECIFIED
Guvenc, BirolUNSPECIFIED
Turgut, MehmetUNSPECIFIED
Ozet, Gulsum GulistanUNSPECIFIED
Ali, RidvanUNSPECIFIED
Masliak, ZvenyslavaUNSPECIFIED
Kyselyova, MarynaUNSPECIFIED
Glushko, NataliiaUNSPECIFIED
Vybyrana, RenataUNSPECIFIED
Skrypnyk, IgorUNSPECIFIED
Tretyak, NatalyaUNSPECIFIED
Kharchevska, TetianaUNSPECIFIED
Dyagil, IrynaUNSPECIFIED
Popovs'ka, TetianaUNSPECIFIED
Shimanskiy, VadimUNSPECIFIED
Lysa, TamilaUNSPECIFIED
Oliynyk, HannaUNSPECIFIED
Vilchevskaya, KaterynaUNSPECIFIED
Kryachok, IrynaUNSPECIFIED
Popovych, YuriyUNSPECIFIED
Romanyuk, NataliaUNSPECIFIED
Yushchenko, NataliaUNSPECIFIED
Kaplan, PolinaUNSPECIFIED
Rekhtman, GrygoriyUNSPECIFIED
Pylypenko, HalynaUNSPECIFIED
Kozlov, ViktorUNSPECIFIED
Mohty, MohamadUNSPECIFIED
Terpos, EvangelosUNSPECIFIED
Mateos, Maria-VictoriaUNSPECIFIED
Palumbo, AntonioUNSPECIFIED
Drach, JohannesUNSPECIFIED
Boccadoro, MarioUNSPECIFIED
Harousseau, Jean-LucUNSPECIFIED
Einsele, HermannUNSPECIFIED
Goldschmidt, HartmutUNSPECIFIED
Facon, ThierryUNSPECIFIED
Michalet, MauricetteUNSPECIFIED
Savchenko, Valery G.UNSPECIFIED
De la Rubia, JavierUNSPECIFIED
Cook, GordonUNSPECIFIED
Mellqvist, Ulf-HenrikUNSPECIFIED
Ludwig, HeinzUNSPECIFIED
Date: October 2018
Date Deposited: 18 Sep 2019 08:04
Last Modified: 18 Sep 2019 08:04
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/3355

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