Degoricija, Vesna and Trbušić, Matias and Potočnjak, Ines and Radulović, Bojana and Terešak, Sanda Dokoza and Pregartner, Gudrun and Berghold, Andrea and Tiran, Beate and Frank, Saša (2018) Acute heart failure developed as worsening of chronic heart failure is associated with increased mortality compared to de novo cases. Scientific Reports, 8 (1). p. 9587. ISSN 2045-2322
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Abstract
Acute heart failure (AHF) emerges either de novo or from worsening of chronic heart failure (CHF). The aim of the present study was to evaluate the association between worsening of CHF and mortality in AHF patients. Out of 152 included AHF patients, 47 (30.9%) were de novo AHF patients and 105 (69%) were AHF patients with worsening of CHF. The proportion dying in hospital (19.0% vs. 4.3%, p = 0.023) and within 3 months after hospitalization (36.6% vs. 6.7%, p < 0.001) was significantly higher in AHF patients with worsening of CHF. Logistic regression analyses also showed a significant positive association of AHF emerging as worsening of CHF with hospital mortality [odds ratio (OR) and 95% confidence interval (CI): 5.29 (1.46-34.10), p = 0.029] and 3-month mortality [8.09 (2.70-35.03), p = 0.001]. While the association with hospital mortality was no longer significant after adjusting for comorbidities and clinical as well as laboratory parameters known to be associated with mortality in heart failure patients, the association with 3-month mortality remained significant. We conclude that compared to de novo AHF, AHF evolved from worsening of CHF is a more severe condition and is associated with increased mortality.
| Item Type: | Article | ||||||||||||||||||||
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| Additional Information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2018 | ||||||||||||||||||||
| Departments: | Katedra za internu medicinu | ||||||||||||||||||||
| Depositing User: | Kristina Berketa | ||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||
| Creators: |
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| Date: | 25 June 2018 | ||||||||||||||||||||
| Date Deposited: | 18 Sep 2019 07:50 | ||||||||||||||||||||
| Last Modified: | 25 Aug 2020 07:23 | ||||||||||||||||||||
| Subjects: | / | ||||||||||||||||||||
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| URI: | http://medlib.mef.hr/id/eprint/3353 |
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