High-risk HPV infection in Kosovar female population

Zejnullahu Raçi, Pranvera (2019) High-risk HPV infection in Kosovar female population. PhD thesis, Sveučilište u Zagrebu.

PDF Download (1MB)

Abstract

Objectives: Kosovo’s current health care system does not support organized nationwide cervical cancer screening and human papillomavirus (HPV) vaccination programs. To date, no reliable data are available on cervical cancer incidence and mortality in Kosovo, or on high-risk HPV (hr-HPV) prevalence and HPV type distribution. Our aim is to determinate the prevaccination prevalence and distribution of hr-HPVs and to assesses the associations between sociodemographic characteristics and increased risk of HPV infection in women from Kosovo. ----- Methods: Detection of hr-HPV DNA was performed in cervical swabs of women that underwent routine gynecological and cytological evaluation by using a clinically validated Abbott RealTime High Risk HPV test, Roche Linear Array HPV Genotyping Test, HPV52 type-specific real-time PCR and an inhouse GP5+/GP6+/68 PCR. ----- Results: The crude overall prevalence of any of the hr-HPVs was estimated at 13.1% (26/199; 95% confidence interval (CI): 9.1–18.5%), with HPV16 being the most common type (7/26; 26.9%), followed by HPV31 and HPV51, each detected in 4/26 (15.4%) cervical specimens, HPV18, detected in 3/26 (11.5%) specimens, HPV52 and HPV66, each detected in 2/26 (7.7%) specimens, and HPV33, HPV45, HPV56, and HPV58, each detected in a single (3.9%) specimen. Women over 40 (OR = 0.36), older than 18 at sexual debut (odds ratio (OR) = 0.28), those that had delivered at least one child (OR = 0.32), and those that had a history of pregnancy termination (OR = 0.39) were at lower risk for HPV infection. ----- Conclusion: Because more than 70% of cervical precancerous lesions could have been prevented in Kosovo using nationwide HPV-based cervical cancer screening and HPV vaccination, it is of outmost importance to implement both programs in the national health care system as soon as possible.

Abstract in Croatian

Ciljevi: Trenutačni sustav zdravstvene zaštite Kosova ne podržava organizirani nacionalni probir karcinoma vrata maternice i program cijepljenja protiv human papiloma virusa (HPV). Do sada, nisu dostupni pouzdani podaci o incidenciji i mortalitetu raka vrata maternice na Kosovu, takoder ni o prevalencije visokorizičnih HPV-a i raspodjela HPV tipova. Cilj nam je utvrditi prevalenciju i raspodjelu visokorizičnih HPV tipova prije cijepljenja i procijeniti povezanost sociodemografskih obilježja i povećanog rizika od HPV infekcije u žena s Kosova. ----- Metode: Detekcija DNK visokorizičnih HPV tipova u cervikalnim obriscima žena koje su bile na rutinskoj ginekološkoj i citološkoj obradi provedena je primjenom klinički validiranog HPV testa, Abbott RealTime HPV testa, Roche Linear Array HPV genotipizacijskog testa, HPV52 tip-specifičnog realnog PCRa i GP5 + / GP6 + / 68 PCR. ----- Rezultati: Ukupna prevalencija svih HPV-a visokog rizika procijenjena je na 13,1% (26/199, 95% intervala pouzdanosti (CI): 9,1-18,5%), pri čemu je HPV16 najčešći tip (7/26; 26,9 %), zatim HPV31 i HPV51, od kojih je svaki detektiran u 4/26 (15,4%) cervikalnih uzoraka, HPV18, detektiran u 3/26 (11,5%) uzoraka, HPV52 i HPV66, svaki detektiran u 2/26 (7,7%) uzoraka , i HPV33, HPV45, HPV56 i HPV58, svaki detektiran u jednom (3,9%) uzorku. Žene iznad 40 godina (OR = 0,36), starije od 18 godina pri prvom spolnom odnosu (omjer vjerojatnosti (OR) = 0,28), one koji su rodile barem jedno dijete (OR = 0,32), i one koje su imale prestanak trudnoće (OR= 0,39) imale su niži rizik za HPV infekciju. ----- Zaključak: Obzirom na to da bi se na Kosovu moglo spriječiti više od 70% prekanceroznih lezija vrata maternice pomoću HPV cjepiva protiv raka vrata maternice i cjepiva protiv HPV-a na nacionalnoj razini, od najveće je važnosti što prije implementirati preventivne programe u nacionalnom zdravstvenom sustavu.

Actions (login required)

View Item

Downloads