Rojnić Kuzman, Martina and Bošnjak Kuharić, Dina and Kekin, Ivana and Makarić, Porin and Madžarac, Zoran and Koričančić Makar, Ana and Kudlek Mikulić, Suzan and Bajić, Žarko and Bistrović, Petra and Bonacin, Dora and Vogrinc, Željka (2018) Effects of long-term multimodal psychosocial treatment on antipsychotic-induced metabolic changes in patients with first episode psychosis. Frontiers in Psychiatry, 9. p. 488. ISSN 1664-0640
![[img]](http://medlib.mef.hr/style/images/fileicons/application_pdf.png) |
PDF
Download (137kB) |
Abstract
Background: Antipsychotic-induced weight gain and metabolic abnormalities are one of the major challenges in the treatment of psychosis, contributing to the morbidity, mortality and treatment non-adherence. Different approaches were used to counteract these side effects but showed only limited or short-term effects. This study aims to analyse the effects of a long-term multimodal treatment program for first episode psychosis on antipsychotic-induced metabolic changes. ----- Methods: We enrolled 71 patients with first episode psychosis treated at the Zagreb University Hospital Centre from 2016 until 2018. Participants were assigned to one of the two groups: day hospital program vs. treatment as usual (TAU). Outcomes were: body weight, blood glucose, lipids and cholesterol, psychopathology and global level of functioning during the 18-months follow-up. ----- Results: Although the TAU group gained more weight and had higher increase of blood glucose, while the day hospital group had a higher increase in total cholesterol at 18th month follow-up, after the adjustment for age, gender and baseline measures, the type of treatment was not significantly associated with any of the primary outcome measures. Patients' psychopathology measures significantly decreased and their functional level significantly increased at month 18th in both groups. ----- Conclusion: While both types of treatment were effective in reducing psychopathology and restoring the patients' level of functioning, both were relatively ineffective in counteracting antipsychotic-induced metabolic abnormalities and antipsychotic-induced weight gain.
| Item Type: | Article | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Additional Information: | Copyright © 2018 Rojnic Kuzman, Bosnjak Kuharic, Kekin, Makaric, Madzarac, Koricancic Makar, Kudlek Mikulic, Bajic, Bistrovic, Bonacin and Vogrinc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | ||||||||||||||||||||||||
| Departments: | Katedra za neurologiju | ||||||||||||||||||||||||
| Depositing User: | Anja Majstorović | ||||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||||
| Creators: |
|
||||||||||||||||||||||||
| Date: | 16 October 2018 | ||||||||||||||||||||||||
| Date Deposited: | 26 Jun 2019 09:34 | ||||||||||||||||||||||||
| Last Modified: | 26 Jun 2019 09:34 | ||||||||||||||||||||||||
| Subjects: | / | ||||||||||||||||||||||||
| Related URLs: | |||||||||||||||||||||||||
| URI: | http://medlib.mef.hr/id/eprint/3310 |
Actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
