An update on the management of young-onset Parkinson's disease

Klepac, Nataša and Habek, Mario and Adamec, Ivan and Barušić, Anabella Karla and Bach, Ivo and Margetić, Eduard and Lušić, Ivo (2013) An update on the management of young-onset Parkinson's disease. Degenerative Neurological and Neuromuscular Disease, 3. pp. 53-56. ISSN 1179-9900

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In the text that follows, we review the main clinical features, genetic characteristics, and treatment options for Parkinson's disease (PD), considering the age at onset. The clinical variability between patients with PD points at the existence of subtypes of the disease. Identification of subtypes is important, since a focus on homogenous group may lead to tailored treatment strategies. One of the factors that determine variability of clinical features of PD is age of onset. Young-onset Parkinson's disease (YOPD) is defined as parkinsonism starting between the ages of 21 and 40. YOPD has a slower disease progression and a greater incidence and earlier appearance of levodopa-induced motor complications; namely, motor fluctuations and dyskinesias. Moreover, YOPD patients face a lifetime of a progressive disease with gradual worsening of quality of life and their expectations are different from those of their older counterparts. Knowing this, treatment plans and management of symptoms must be paid careful attention to in order to maintain an acceptable quality of life in YOPD patients.

Item Type: Article
Additional Information: © 2013 Klepac et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Ltd. Information on how to request permission may be found at:
Departments: Katedra za kirurgiju
Depositing User: Anja Majstorović
Status: Published
Barušić, Anabella KarlaUNSPECIFIED
Margetić, EduardUNSPECIFIED
Date: 4 October 2013
Date Deposited: 10 Jun 2019 10:09
Last Modified: 13 Jul 2020 10:25
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