Povezanost pojave peritumoralnih pukotina u duktalnom invazivnom karcinomu dojke s miofibroblastičnom reakcijom strome [The correlation of peritumoral clefts with myofibroblastic stromal reaction in invasive ductal breast carcinoma]

Leniček, Tanja and Kos, Marina (2018) Povezanost pojave peritumoralnih pukotina u duktalnom invazivnom karcinomu dojke s miofibroblastičnom reakcijom strome [The correlation of peritumoral clefts with myofibroblastic stromal reaction in invasive ductal breast carcinoma]. Liječnički vjesnik, 140 (7-8). pp. 190-199. ISSN 0024-3477

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Abstract

Aim: To determine the correlation of peritumoral retraction clefts and myofibroblastic stromal reaction in invasive breast carcinomas of no special type. Methods: Peritumoral clefts were analyzed in 100 invasive ductal breast carcinomas. Stromal reaction was analyzed immunohistochemically with CD34, vimentin and smooth muscle actin (SMA). Results: Peritumoral clefts were found in 92% of invasive carcinoma tissue and were absent in surrounding normal tissue and around ducts of in situ component. The extent of peritumoral clefts ranged from 5% to 100% andcorrelated significantly with the quantityof SMA+ stromal myofibroblasts, increased tumor size, pT stage, presence of lymph node metastasis and the rate of positive lymph nodes. Extensive peritumoral clefts (in >30% of tumor tissue) correlated significantly with higher quantity of SMA+ myofibroblasts, higher frequency of lymph node metastases and higher rate of positive lymph nodes. Conclusion: Peritumoral retraction clefts are morphological expression of the phenotypic changes of tumor stromal cell that acquire myofibroblastic characteristics.

Abstract in Croatian

Cilj: Utvrditi postoji li povezanost između peritumoralnih pukotina i miofi broblastične reakcije strome u duktalnim invazivnim karcinomima dojke bez posebnih obilježja. Metode: U 100 invazivnih duktalnih karcinoma dojke u žena analizirani su postojanje peritumoralnih pukotina i imunohistokemijska izraženost CD34, vimentina i glatkomišićnog aktina (SMA) u tumorskoj stromi. Rezultati: Peritumoralne pukotine nađene su u 92% karcinoma, dok u okolnom tkivu i oko žarišta duktalnog karcinoma in situ nisu nađene. Proširenost pukotina bila je 5 do 100%. Apsolutni postotak peritumoralnih pukotina bio je znatno povezan s količinom SMA+ miofibroblasta u stromi, veličinom tumora i pT stadijem bolesti, prisutnošću metastaza u aksilarnim limfnim čvorovima i udjelom pozitivnih limfnih čvorova. Tumori s opsežno izraženim peritumoralnim pukotinama (u > 30% tumora) imali su znatno veću količinu SMA+ miofibroblasta u stromi, češće metastaze u aksilarne limfne čvorove i veći udio pozitivnih limfnih čvorova. Zaključak: Peritumoralne pukotine morfološki su izraz promijenjenih osobina tumorske strome u obliku zadobivanja miofi broblastičnog fenotipa.

Item Type: Article
Departments: Katedra za patologiju
Depositing User: Anja Majstorović
Status: Published
Creators:
CreatorsEmail
Leniček, TanjaUNSPECIFIED
Kos, MarinaUNSPECIFIED
Date: July 2018
Date Deposited: 03 Apr 2019 11:49
Last Modified: 03 Apr 2019 11:49
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/3206

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