Utjecaj fitosterola na omjer debljina intime i medije karotidnih i femoralnih arterija te metaboličke pokazatelje u bolesnika s metaboličkim sindromom [Phytosterol effects on carotid and femoral IMT and metabolic parameters in patients with metabolic syndrome]

Mazalin Protulipac, Josipa (2016) Utjecaj fitosterola na omjer debljina intime i medije karotidnih i femoralnih arterija te metaboličke pokazatelje u bolesnika s metaboličkim sindromom [Phytosterol effects on carotid and femoral IMT and metabolic parameters in patients with metabolic syndrome]. PhD thesis, Sveučilište u Zagrebu.

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Abstract

Phytosterols are natural plant compounds, structurally related to cholesterol. In human body, they are solely of dietary origin; their positive effect on serum cholesterol level reduction is very well documented. However, so far there has been no research on phytosterol effect on arterial intima media thickness (IMT), and research on its effect on metabolic parameters in patients diagnosed with metabolic syndrome are rare. This placebo controlled double blind study monitored a. carotis and a. femoralis IMT in 82 patients diagnosed with metabolic syndrome, which (in addition to their regular therapy) received phytosterol (2 g a day, for a period of one year), or placebo.In both study groups regular metabolic parameters (total, LDL/HDL cholesterol, triglycerides, glucose, CRP, fibrinogen, adiponectin, leptin) were also monitored. We found that phytosterol lowered total cholesterol in phytosterol group by 2% (p=0,023), but there was no significant effect on other metabolic parameters. Also, we didn’t observe any significant IMT changes. Further studies are needed to better explain clinical benefits of phytosterol intake, both in healthy and MS population.

Abstract in Croatian

Fitosteroli su prirodni sastojci biljaka, koje u organizam unosimo putem hrane, a njihov utjecaj na smanjenje koncentracije kolesterola u plazmi dobro je istražen. Do sada nije bilo istraživanja u kojima se procjenjivao utjecaj fitosterola na promjene omjera debljine intime i medije arterija, a vrlo malo je istraživanja u kojima se ispitivao njegov učinak kod bolesnika s metaboličkim sindromom. Temelj ove Disertacije bilo je dvostruko slijepo placebom kontrolirano istraživanje na 82 bolesnika s meteboličkim sindromom, koji su uz redovnu terapiju hipolipemicima tijekom godine dana uzimali fitosterol (2 grama na dan) ili placebo. U tih bolesnika pratili smo omjer debljina intime i medije karotidnih i femoralnih arterija, kao i uobičajene metaboličke pokazatelje (ukupni te LDL i HDL kolesterol, trigliceride, glukozu, CRP, fibrinogen, adiponektin, leptin). Naši rezultati pokazali su da nakon godine dana primjene fitosterola dolazi do smanjenja ukupnog kolesterola u bolesnika s metaboličkim sindromom za 2% (p=0,023). Nismo pronašli značajnije promjene drugih metaboličkih parametara, niti smo potvrdili osnovnu hipotezu rada – nije bilo promjene omjera debljina intime i medije karotidnih i femoralnih arterija. Potrebna su daljnja istraživanja duljeg trajanja, kako bi se detaljnije istražio klinički značaj primjene fitosterola, kako u zdravoj, tako i u populaciji velikog kardiovaskularnog rizika.

Item Type: Thesis (PhD)
Mentors:
Mentor
Reiner, Željko
Departments: Izvan medicinskog fakulteta
Depositing User: dr.med. Helena Markulin
University: Sveučilište u Zagrebu
Institution: Medicinski fakultet
Number of Pages: 128
Status: Unpublished
Creators:
CreatorsEmail
Mazalin Protulipac, JosipaUNSPECIFIED
Date: 23 December 2016
Date Deposited: 02 Oct 2018 08:18
Last Modified: 02 Oct 2018 08:18
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/2998

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